K
Kumar Sharma
Researcher at University of Texas Health Science Center at San Antonio
Publications - 290
Citations - 23481
Kumar Sharma is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Diabetes mellitus & Kidney disease. The author has an hindex of 72, co-authored 239 publications receiving 19918 citations. Previous affiliations of Kumar Sharma include Veterans Health Administration & Vanderbilt University.
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Journal ArticleDOI
Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Kevin J. Pearson,Joseph A. Baur,Kaitlyn N. Lewis,Leonid Peshkin,Nathan L. Price,Nathan L. Price,Nazar Labinskyy,William R. Swindell,Davida Kamara,Robin K. Minor,Evelyn Perez,Hamish A. Jamieson,Yongqing Zhang,Stephen R. Dunn,Kumar Sharma,Nancy Pleshko,Laura A. Woollett,Anna Csiszar,Yuji Ikeno,David G. Le Couteur,Peter J. Elliott,Kevin G. Becker,Plácido Navas,Donald K. Ingram,Norman S. Wolf,Zoltan Ungvari,David A. Sinclair,Rafael de Cabo +27 more
TL;DR: It is found that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
Journal ArticleDOI
KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update
Rudolf W. Bilous,JM Gonzalez-Campoy,JE Fradkin,Michael Mauer,Mark E. Molitch,Andrew S. Narva,Robert G. Nelson,Kumar Sharma,Katherine R. Tuttle,Michael V. Rocco,Jeffrey S. Berns,Timothy J Wilt,Areef Ishani,Thomas S. Rector,Yelena Slinin,Patrick Fitzgerald,M Carlyle +16 more
TL;DR: The 2012 update of the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guideline for Diabetes and Chronic Kidney disease (CKD) is intended to assist the practitioner caring for patients with diabetes and CKD.
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Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody in db/db diabetic mice
Fuad N. Ziyadeh,Brenda B. Hoffman,Dong Cheol Han,M. Carmen Iglesias-de la Cruz,Soon Won Hong,Motohide Isono,Sheldon Chen,Tracy A. McGowan,Kumar Sharma +8 more
TL;DR: It is concluded that chronic inhibition of the biologic actions of TGF-beta with a neutralizing monoclonal antibody in db/db mice prevents the glomerulosclerosis and renal insufficiency resulting from type 2 diabetes.
Journal ArticleDOI
Mouse Models of Diabetic Nephropathy
Frank C. Brosius,Charles E. Alpers,Erwin P. Bottinger,Matthew D. Breyer,Thomas M. Coffman,Susan B. Gurley,Raymond C. Harris,Masao Kakoki,Matthias Kretzler,Edward H. Leiter,Moshe Levi,Richard A. McIndoe,Kumar Sharma,Oliver Smithies,Katalin Susztak,Nobuyuki Takahashi,Takamune Takahashi +16 more
TL;DR: This interim report and an online supplement detail the progress made toward a complete murine model of human diabetic kidney disease and the critical analysis of existing murine models, which substantially enhances the understanding of this disease process.
Journal ArticleDOI
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development
Hyun Mi Kang,Seon Ho Ahn,Peter S. Choi,Yi-An Ko,Seung Hyeok Han,Frank Chinga,Ae Seo Deok Park,Jianling Tao,Kumar Sharma,James Pullman,Erwin P. Bottinger,Ira J. Goldberg,Katalin Susztak +12 more
TL;DR: It is found that humans and mouse models with tubulointerstitial fibrosis had lower expression of key enzymes and regulators of fatty acid oxidation (FAO) and higher intracellular lipid deposition compared to controls, raising the possibility that correcting the metabolic defect in FAO may be useful for preventing and treating chronic kidney disease.