Shinsuke Takagawa

TL;DR: The results suggest that dermal sclerosis induced by BLM closely resembles systemic sclerosis both histologically and biochemically.

TL;DR: The data suggest that the STAT6 signal plays a critical role in the induction phase of CHS, and adoptive transfer experiments revealed that STAT6−/− mice induced CHS after injection of lymph node cells obtained from sensitized wt mice.

TL;DR: Results show that mast cell is not necessary for inducing Dermal sclerosis by bleomycin, and other types of inflammatory cells such as infiltrating macrophages or T lymphocytes may play a role in triggering induction of dermal sclerosis via fibrogenic cytokines.

TL;DR: Systemic PC-superoxide dismutase markedly inhibited the development of dermal sclerosis, which was also accompanied by a decrease in the number of infiltrating mast cells and eosinophils, which indicates that administration of superoxide dismUTase may be effective in the therapeutic approach in systemic sclerosis.

TL;DR: HGF-gene transfection both prevented and ameliorated the symptoms of not only dermal sclerosis but also of lung fibrosis induced by a subcutaneous BLM injection, indicating that gene therapy by the transfections of the human HGF cDNA may be a useful therapy for SSc and lung fibritis involved with SSc.