H
Hiroo Yokozeki
Researcher at Tokyo Medical and Dental University
Publications - 362
Citations - 5267
Hiroo Yokozeki is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Atopic dermatitis & Immunoglobulin E. The author has an hindex of 32, co-authored 355 publications receiving 4653 citations. Previous affiliations of Hiroo Yokozeki include Fukushima Medical University.
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Basophils Play a Critical Role in the Development of IgE-Mediated Chronic Allergic Inflammation Independently of T Cells and Mast Cells
Kaori Mukai,Kunie Matsuoka,Choji Taya,Hidenori Suzuki,Hiroo Yokozeki,Kiyoshi Nishioka,Katsuiku Hirokawa,Maki Etori,Makoto Yamashita,Toshiyuki Kubota,Yoshiyuki Minegishi,Hiromichi Yonekawa,Hajime Karasuyama +12 more
TL;DR: It is shown that basophils are responsible for the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells, and transfer of FcRI-expressing basophil into Fc RI-deficient mice restored theDevelopment of the delayed-onset allergic inflammation.
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Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks
Takeshi Wada,Kenji Ishiwata,Haruhiko Koseki,Tomoyuki Ishikura,Tsukasa Ugajin,Naotsugu Ohnuma,Kazushige Obata,Ryosuke Ishikawa,Soichiro Yoshikawa,Kaori Mukai,Yohei Kawano,Yoshiyuki Minegishi,Hiroo Yokozeki,Naohiro Watanabe,Hajime Karasuyama +14 more
TL;DR: Investigation of the cellular and molecular mechanisms underlying acquired resistance to Haemaphysalis longicornis ticks in mice found that antibodies were required, as was IgFc receptor expression on basophils but not on mast cells, and that basophil infiltration to acquired tick resistance was required.
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Basophil recruitment and activation in inflammatory skin diseases
TL;DR: This data indicates that Basophil recruitment and activation in inflammatory skin diseases is driven by a single substance called “basophil B”, which acts as a “spatially aggregating force” to spruce up the immune system.
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Prostaglandin D2 Plays an Essential Role in Chronic Allergic Inflammation of the Skin via CRTH2 Receptor
Takahiro Satoh,Rie Moroi,Kosuke Aritake,Yoshihiro Urade,Yasumasa Kanai,Koji Sumi,Hiroo Yokozeki,Hiroyuki Hirai,Kinya Nagata,Toshifumi Hara,Masanori Utsuyama,Katsuiku Hirokawa,Kazuo Sugamura,Kiyoshi Nishioka,Masataka Nakamura +14 more
TL;DR: In models of chronic contact hypersensitivity induced by repeated hapten application, CRTH2 deficiency resulted in a reduction by approximately half of skin responses and low levels of serum IgE production, which indicates that the PGD2-CRTH2 system plays a significant role in chronic allergic skin inflammation.
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Basophils preferentially express mouse mast cell protease 11 among the mast cell tryptase family in contrast to mast cells
Tsukasa Ugajin,Toshiyuki Kojima,Kaori Mukai,Kazushige Obata,Yohei Kawano,Yoshiyuki Minegishi,Yoshinobu Eishi,Hiroo Yokozeki,Hajime Karasuyama +8 more
TL;DR: This is the first study to demonstrate that mouse basophils produce a trypsin‐like protease, and it is shown that mMCP‐11 proteins are indeed expressed by primary basophil and those infiltrating the affected tissues during allergic inflammation and parasitic infections.