S
Shirley M. Clift
Researcher at Johns Hopkins University School of Medicine
Publications - 7
Citations - 1791
Shirley M. Clift is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Immune system & GVAX. The author has an hindex of 7, co-authored 7 publications receiving 1761 citations. Previous affiliations of Shirley M. Clift include Johns Hopkins University.
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Journal ArticleDOI
Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma
Robert J. Soiffer,Thomas R. Lynch,Martin C. Mihm,Kenneth Jung,Catherine Rhuda,Jan C. Schmollinger,F S Hodi,L Liebster,P Lam,Steven J. Mentzer,Samuel Singer,Kenneth K. Tanabe,Cosimi Ab,Rosemary B. Duda,Arthur J. Sober,Atul K. Bhan,John F. Daley,Donna Neuberg,Gareth Parry,J Rokovich,L Richards,J Drayer,Anton Berns,Shirley M. Clift,Lawrence K. Cohen,Richard C. Mulligan,Glenn Dranoff +26 more
TL;DR: It is demonstrated that vaccination with irradiated autologous melanoma cells engineered to secrete granulocyte-macrophage colony-stimulating factor stimulates potent antitumor immunity in humans with metastatic melanoma.
Journal Article
Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer
Jonathan W. Simons,Bahar Mikhak,Ju-Fay Chang,Angelo M. DeMarzo,Michael A. Carducci,Michael Lim,Christine E. Weber,Angelo A. Baccala Md,Marti Goemann,Shirley M. Clift,Dale G. Ando,Hyam I. Levitsky,Lawrence K. Cohen,Martin G. Sanda,Richard C. Mulligan,Alan W. Partin,H. Ballentine Carter,Steven Piantadosi,Fray F. Marshall,William G. Nelson +19 more
TL;DR: It is suggested that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines, and side effects were pruritus, erythema, and swelling at vaccination sites.
Journal Article
Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by ex Vivo Granulocyte-Macrophage Colony-stimulating Factor Gene Transfer
Jonathan W. Simons,Elizabeth M. Jaffee,Christine E. Weber,Hyam I. Levitsky,William G. Nelson,Michael A. Carducci,Audrey J. Lazenby,Lawrence K. Cohen,Christy C. Finn,Shirley M. Clift,Karen M. Hauda,Lisa A. Beck,Kristin M. Leiferman,Albert H. Owens,Steven Piantadosi,Glenn Dranoff,Richard C. Mulligan,Drew M. Pardoll,Fray F. Marshall +18 more
TL;DR: This Phase I study demonstrated the feasibility, safety, and bioactivity of an autologous GM-CSF gene-transduced tumor vaccine for RCC patients.
Journal ArticleDOI
Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naïve prostate cancer.
Jonathan W. Simons,Michael A. Carducci,Bahar Mikhak,Michael Lim,Barbara A. Biedrzycki,Flavia Borellini,Shirley M. Clift,Kristen Hege,Dale G. Ando,Steven Piantadosi,Richard C. Mulligan,William G. Nelson +11 more
TL;DR: This non-patient-specific prostate cancer immunotherapy has a favorable safety profile and is immunologically active and continued clinical investigation at higher doses and with longer boosting schedules is warranted.
Journal ArticleDOI
Cancer cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer as vaccines for the treatment of genitourinary malignancies
William G. Nelson,Jonathan W. Simons,Bahar Mikhak,Ju Fay Chang,Angelo M. DeMarzo,Michael A. Carducci,Michael M. Kim,Christine E. Weber,Angelo A. Baccala Md,Marti A. Goeman,Shirley M. Clift,Dale G. Ando,Hyam I. Levitsky,Lawrence K. Cohen,Martin G. Sanda,Richard C. Mulligan,Alan W. Partin,H. Ballentine Carter,Steven Piantadosi,Fray F. Marshall +19 more
TL;DR: These first clinical trials of GM-CSF-secreting cancer cell vaccines for the treatment of genitourinary cancers have demonstrated both safety and bioactivity, in that very few side effects have been seen and anticancer immune responses have been detected.