S
Shizuya Yamashita
Researcher at Otsuka Pharmaceutical
Publications - 3
Citations - 3041
Shizuya Yamashita is an academic researcher from Otsuka Pharmaceutical. The author has contributed to research in topics: Adipocyte & Adiponectin. The author has an hindex of 3, co-authored 3 publications receiving 2958 citations.
Papers
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Journal ArticleDOI
Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway
Noriyuki Ouchi,Shinji Kihara,Yukio Arita,Yoshihisa Okamoto,Kazuhisa Maeda,Hiroshi Kuriyama,Kikuko Hotta,Makoto Nishida,Masahiko Takahashi,Masahiro Muraguchi,Yasukazu Ohmoto,Tadashi Nakamura,Shizuya Yamashita,Tohru Funahashi,Yuji Matsuzawa +14 more
TL;DR: The possibility that adiponectin, which is naturally present in the blood stream, modulates the inflammatory response of endothelial cells through cross talk between cAMP-PKA and NF-&kgr;B signaling pathways is raised.
Journal ArticleDOI
Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages
Noriyuki Ouchi,Shinji Kihara,Yukio Arita,Makoto Nishida,Akifumi Matsuyama,Yoshihisa Okamoto,Masato Ishigami,Hiroshi Kuriyama,Ken Kishida,Hitoshi Nishizawa,Kikuko Hotta,Masahiro Muraguchi,Yasukazu Ohmoto,Shizuya Yamashita,Tohru Funahashi,Yuji Matsuzawa +15 more
TL;DR: The adipocyte-derived plasma protein adiponectin suppressed macrophage-to-foam cell transformation, suggesting that adip onectin may act as a modulator for macrophages- to-foams cell transformation.
Patent
Pharmaceutical composition comprising substance capable of inhibiting or promoting progranulin activity and screening method for substance capable of inhibiting or promoting progranulin activity
TL;DR: In this paper, a pharmaceutical composition for the treatment or prevention of a disease induced by the increased fat tissues/cells and/or a disease caused by increased macrophage activity is presented.