Shobini Jayaraman

TL;DR: DARR is shown to be more effective than RFDR in recoupling long-range dipolar interactions in model systems and 13C-13C correlations can be obtained in non-crystalline integral membrane proteins reconstituted into lipid membranes containing less than 150 nmoles of protein.

TL;DR: It is suggested that high structural stability and resistance to proteolysis of SAA oligomers at pH 3.5–4.5 help them escape lysosomal degradation, promote SAA accumulation in lysOSomes, and ultimately damage cellular membranes and liberate intracellular amyloid.

TL;DR: The results suggest that structural perturbations in the amyloid‐prone segments trigger α‐helix to β‐sheet conversion in the N‐terminal ~ 75 residues forming theAmyloid core, a novel mechanism that suggests potential therapeutic interventions for apoA‐I isyloidosis.

TL;DR: Analysis of the effects of various salts, sucrose, and pH suggests that HDL destabilization by salt results from ionic screening of favorable short-range electrostatic interactions such as salt bridges, which significantly contribute to the high thermostability of HDL in low-salt solutions.

TL;DR: An ensemble of apolipoprotein conformations on various HDL is postulate, hypothesizing that endogenous apoA-II helps confer lipid surface curvature during conversion of nascent discoidal HDL and HDL containing either apo-I or apo a-II to mature spherical HDL containing both proteins, and hinders remodeling of HDL by hindering the expansion of the apo A-I conformation.