S
Shoen Kume
Researcher at Tokyo Institute of Technology
Publications - 119
Citations - 5384
Shoen Kume is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 33, co-authored 111 publications receiving 4958 citations. Previous affiliations of Shoen Kume include Osaka University & Center for Excellence in Education.
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Journal ArticleDOI
Insulin staining of ES cell progeny from insulin uptake.
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Dopamine Is a Regulator of Arousal in the Fruit Fly
TL;DR: It is shown that fmn mutants have abnormally high levels of activity and reduced rest (sleep); genetic mapping, molecular analyses, and phenotypic rescue experiments demonstrate that these phenotypes result from mutation of the Drosophila dopamine transporter gene.
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Methionine Metabolism Regulates Maintenance and Differentiation of Human Pluripotent Stem Cells
Nobuaki Shiraki,Yasuko Shiraki,Tomonori Tsuyama,Fumiaki Obata,Masayuki Miura,Genta Nagae,Hiroyuki Aburatani,Kazuhiko Kume,Kazuhiko Kume,Fumio Endo,Shoen Kume +10 more
TL;DR: The authors showed that methionine deficiency in human ESCs/iPSCs triggers activation of p53-p38 signaling, reducing NANOG expression, and poising human iPSC/ESCs for differentiation, followed by potentiated differentiation into all three germ layers.
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The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos.
TL;DR: Data indicate that XNF-AT functions as a downstream target of the Wnt/Ca2+ and Ins(1,4,5)P3- Ca2+ pathways, and has an essential role in mediating ventral signals in the Xenopus embryo through suppression of the canonical Wnt pathway.
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Identification of a dopamine pathway that regulates sleep and arousal in Drosophila
TL;DR: It is found that the D1 dopamine receptor (DA1) in the dorsal fan-shaped body (dFSB) mediates the arousal effect of dopamine in Drosophila and suggests that a local dopamine pathway regulates sleep.