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Shogo Nagata
Researcher at University of Tokyo
Publications - 28
Citations - 347
Shogo Nagata is an academic researcher from University of Tokyo. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 7, co-authored 23 publications receiving 283 citations. Previous affiliations of Shogo Nagata include Kyoto University.
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Journal ArticleDOI
Efficient reprogramming of human and mouse primary extra-embryonic cells to pluripotent stem cells.
Shogo Nagata,Masashi Toyoda,Shinpei Yamaguchi,Kunio Hirano,Hatsune Makino,Koichiro Nishino,Yoshitaka Miyagawa,Hajime Okita,Nobutaka Kiyokawa,Masato Nakagawa,Shinya Yamanaka,Hidenori Akutsu,Akihiro Umezawa,Takashi Tada +13 more
TL;DR: Newborn human and mouse extra‐embryonic amnion and yolk‐sac cells, in which endogenous KLF4/Klf4, c‐MYC/c‐Myc and RONIN/Ronin are expressed, can be reprogrammed to hiPSCs and miPSCs with efficiencies for AM cells of 0.02% and 0.1%, respectively.
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Sox2 expression effects on direct reprogramming efficiency as determined by alternative somatic cell fate.
TL;DR: It is concluded that Sox2 plays a crucial role in a dose-dependent manner in direct reprogramming of somatic cells to iPSCs via conventional OSK as seen by pluripotent marker gene expression and chimera formation.
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Human and Mouse Induced Pluripotent Stem Cells Are Differentially Reprogrammed in Response to Kinase Inhibitors
Kunio Hirano,Shogo Nagata,Shinpei Yamaguchi,Masato Nakagawa,Keisuke Okita,Hidetoshi Kotera,Justin F. X. Ainscough,Takashi Tada +7 more
TL;DR: It is demonstrated that flat-shaped hiPSC colonies can be reprogrammed into bowl-shaped multi-potent stem cells (2i-hiPSCs) by using 2i+LIF medium, and gene expression profiling demonstrated that 2i-HIPSCs more closely resemble primitive neural stem Cells (PNSCs).
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Self-Renewal and Pluripotency Acquired through Somatic Reprogramming to Human Cancer Stem Cells
TL;DR: Findings indicate that pluripotent tumorigenicity can be conferred on somatic cells through up-regulation of the core pluripotency and Myc-related factors, prior to establishment of the iPSC molecular network by full reprogramming through down- regulation of the polycomb complex factor.
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Cell fiber-based three-dimensional culture system for highly efficient expansion of human induced pluripotent stem cells
TL;DR: A scalable culture system using the cell fiber technology for the expansion of human induced pluripotent stem (iPS) cells is described and demonstrated a long-term culture of the cells by serial passaging at a high expansion rate while retaining its pluripotency.