Shoshana Naiman

TL;DR: Male, but not female, transgenic mice overexpressing Sirt6 have a significantly longer lifespan than wild-type mice, and has important therapeutic implications for age-related diseases.

TL;DR: Gene expression analysis of adipose tissue revealed that the positive effect of SIRT6 overexpression is associated with down regulation of a selective set of peroxisome proliferator‐activated receptor‐responsive genes, and genes associated with lipid storage, which were suggested as potential targets for drugs to control metabolic syndrome.

TL;DR: Reciprocally, starved SIRT6 transgenic mice show increased pyruvate, acetylcarnitine, and glycerol levels and significantly induce β-oxidation genes in a PPARα-dependent manner, and a mechanism by which Sirt6 maintains healthy liver is suggested.

TL;DR: This work developed ExpressionBlast, a computational method that uses automated text analysis to identify and merge replicates and determine the type of each array in the series, which allowed us to create the largest collection of computationally annotated expression data currently available.

TL;DR: It is indicated that overexpression of SIRT6 in mice retards important aspects of the aging process and suggested to be a potential therapeutic target for the treatment of a set of age-related disorders.