S
Shu-Chen Chu
Researcher at Central Taiwan University of Science and Technology
Publications - 91
Citations - 3840
Shu-Chen Chu is an academic researcher from Central Taiwan University of Science and Technology. The author has contributed to research in topics: Neuropeptide Y receptor & Cancer cell. The author has an hindex of 32, co-authored 86 publications receiving 3503 citations.
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Journal ArticleDOI
Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line.
TL;DR: The result suggested that anthocyanins could decrease the in vitro invasiveness of cancer cells and therefore, may be of great value in developing a potential cancer therapy.
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Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo.
TL;DR: Two bioactive compounds from O. sativa L. indica were identified and evidenced by their inhibition on the growth of Lewis lung carcinoma cells in vivo, and anthocyanin treatment resulted in a strong inhibitory effect on cell growth via G2/M arrest.
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Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression.
TL;DR: Molecular evidence associated with the anti-metastatic effects of peonidin 3-glucoside and cyanidin3-gl Sucoside, major anthocyanins extracted from black rice, are provided by showing a marked inhibition on the invasion and motility of SKHep-1 cells in vivo.
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Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways.
TL;DR: Findings suggested that the inhibition on MMP-2 and u-PA expression by silibinin may be through a suppression on ERK1/2 or Akt phosphorylation, which in turn led to the reduced invasiness of the cancer cells.
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Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
TL;DR: It is observed that silibinin exerted a dose‐ and time‐dependent inhibitory effect on the invasion and motility, but hardly on the adhesion, of highly metastatic A549 cells in the absence of cytotoxicity.