Shuang Huang

TL;DR: Transcriptional profiling reveals that mouse neuroblastoma sphere-forming cells acquire a metabolic program characterized by transcriptional activation of the cholesterol and serine-glycine synthesis pathways, primarily as a result of increased expression of sterol regulatory element binding factors and Atf4, respectively, which suggests a therapeutic strategy for targeting the metabolic program of high-risk Neuroblastoma.

TL;DR: It is shown that EBV infection increases αv, β3 and β5 integrin subunit mRNAs as well as upregulates the expression of the αvβ3 integrin protein on human B cells, indicating that αv integrins play a significant role in EBV-induced B-lymphocyte proliferation and invasion.

TL;DR: Genome-wide DNA methylation plays a protective role in cisplatin-induced AKI by regulating specific genes, such as Irf8, and interferon regulatory factor 8 (Irf8), a pro-apoptotic factor, was identified as a hypomethylated gene in cisPlatin- induced AKI.

TL;DR: The study suggests that ISL or THC may be safely used as a Src inhibitor, the only licorice’s constituent capable of inhibiting both cell migration and growth.

TL;DR: Evidence is presented that mixtures of bacterial products/components LPS and fMLP behave synergistically in the induction of inflammation in vitro and in vivo, and that the TLR4 and the IKKβ-IκBα signaling pathways are involved in the synergistic induction of inflammatory cytokines.