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Shuangping Shi
Researcher at Cornell University
Publications - 8
Citations - 1088
Shuangping Shi is an academic researcher from Cornell University. The author has contributed to research in topics: Tumor necrosis factor alpha & Pyruvate dehydrogenase complex. The author has an hindex of 7, co-authored 8 publications receiving 1021 citations.
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Journal ArticleDOI
Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis Signaling Roles of Nitric Oxide Synthase-2 and Phagocyte Oxidase
Sabine Ehrt,Dirk Schnappinger,Stefan Bekiranov,Jorg Drenkow,Shuangping Shi,Thomas R. Gingeras,Terry Gaasterland,Gary K. Schoolnik,Carl Nathan +8 more
TL;DR: Studies involving macrophages deficient in inducible nitric oxide synthase and/or phagocyte oxidase revealed that these two antimicrobial enzymes help orchestrate the profound transcriptional remodeling that underlies macrophage activation.
Journal ArticleDOI
MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis
Shuangping Shi,Carl Nathan,Dirk Schnappinger,Jorg Drenkow,Michele Fuortes,Ellen F. Block,Aihao Ding,Thomas R. Gingeras,Gary K. Schoolnik,Shizuo Akira,Kiyoshi Takeda,Sabine Ehrt +11 more
TL;DR: Analysis of the mechanism revealed that MyD88 mediates a process of self-priming by which resting macrophages produce a low level of tumor necrosis factor, which synergizes with IFN-γ for gene induction.
Journal ArticleDOI
Virulence of Mycobacterium tuberculosis Depends on Lipoamide Dehydrogenase, a Member of Three Multienzyme Complexes
Aditya Venugopal,Ruslana Bryk,Shuangping Shi,Kyu Y. Rhee,Poonam Rath,Dirk Schnappinger,Sabine Ehrt,Carl Nathan +7 more
TL;DR: Mycobacterium tuberculosis (Mtb) adapts to persist in a nutritionally limited macrophage compartment and critically requires BCKADH along with PDH and PNR/P for pathogenesis, positioning Lpd as a potential target for anti-infectives against Mtb.
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Mycobacterium tuberculosis appears to lack α-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes
Jing Tian,Ruslana Bryk,Shuangping Shi,Hediye Erdjument-Bromage,Paul Tempst,Paul Tempst,Carl Nathan +6 more
TL;DR: In this paper, a peroxynitrite reductase-peroxidase complex in Mtb was identified, which included products of the genes sucB and lpd, which are annotated to encode the dihydrolipoamide succinyltransferase and lipoamide dehydrogenase (E3) components of α-ketoglutarate deacetyltransferase (KDH).
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Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1.
Shuangping Shi,Antje Blumenthal,Christopher M. Hickey,Sheetal Gandotra,David E. Levy,Sabine Ehrt +5 more
TL;DR: Viable Mtb elicits the expression of inducible NO synthase, RANTES, IFN-inducible protein 10, and IRG1 in macrophages that lack mannose receptor, complement receptors 3 and 4, type A scavenger receptor, or CD40.