S
Shubhankar K. Singh
Researcher at Rajendra Memorial Research Institute of Medical Sciences
Publications - 34
Citations - 355
Shubhankar K. Singh is an academic researcher from Rajendra Memorial Research Institute of Medical Sciences. The author has contributed to research in topics: Leishmania donovani & Visceral leishmaniasis. The author has an hindex of 10, co-authored 32 publications receiving 279 citations.
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Journal ArticleDOI
Leishmania donovani: Assessment of leishmanicidal effects of herbal extracts obtained from plants in the visceral leishmaniasis endemic area of Bihar, India
Shubhankar K. Singh,Sanjiva Bimal,Shyam Narayan,Chandrawati Jee,Devla Bimal,Pradeep Das,Raageeva Bimal +6 more
TL;DR: This study investigated the anti-leishmanial properties of 30 medicinally important plants from the VL endemic area of Bihar, India and compared them to two available anti-toxic drugs and two plant lectins on Leishmania donovani promastigotes in vitro at 24 and 48 h after initiation of culture.
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Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.
Prakash Kumar,Pushkar Shivam,Saptarshi Mandal,Pragya Prasanna,Saurabh Kumar,Surendra Prasad,Ashish Kumar,Prolay Das,Vahab Ali,Shubhankar K. Singh,Debabrata Mandal +10 more
TL;DR: GNP-based delivery of AmB can be a better, cheaper, and safer alternative than available AmB formulations, and improved antileishmanial efficacy and reduced cytotoxicity.
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Leishmania donovani: role of CD2 on CD4+ T-cell function in Visceral Leishmaniasis.
Sanjiva Bimal,Shubhankar K. Singh,Sukrat Sinha,Krishna Pandey,Prabhat K. Sinha,Alok Ranjan,Sujit K. Bhattacharya,Pradeep Das +7 more
TL;DR: Findings imply that infection with L. donovani induces less CD2 on the surface of CD4+ T-cells, which once activated orchestrate the protective IFN-gamma dominant host defense mechanism via PKC-mediated signal transduction and cell cycle.
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Leishmania donovani: dynamics of L. donovani evasion of innate immune cell attack due to malnutrition in visceral leishmaniasis.
Vikash Kumar,Sanjiva Bimal,Shubhankar K. Singh,Rajesh Chaudhary,Sushmita Das,Chandrashekhar Lal,Krishna Pandey,Vidyanand Rabi Das,Pradeep Das +8 more
TL;DR: Malnutrition linked to VL can be a decisive factor in the dynamics of L. donovani evasion of innate immune cell function in VL patients, as revealed by decreased shedding of l-selectin and down-regulation of CD11 b expression on the surface of the PMNs and monocytes.
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Evaluation of rK-39 Strip Test Using Urine for Diagnosis of Visceral Leishmaniasis in an Endemic Region of India
Dharmendra Singh,Krishna Pandey,Vidya Nand Rabi Das,Sushmita Das,Neena Verma,Alok Ranjan,Sekhar Chandra Lal,Kamal Roshan Topno,Shubhankar K. Singh,R. B. Verma,Ashish Kumar,Abul Hasan Sardar,Bidyut Purkait,Pradeep Das +13 more
TL;DR: Considering sensitivity and feasibility of the test in the field, rK-39 ICT using urine samples can be an alternative to conventional invasive VL diagnosis.