S
Shuda Chen
Researcher at Sun Yat-sen University
Publications - 14
Citations - 293
Shuda Chen is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 9 publications receiving 255 citations.
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Journal ArticleDOI
Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland
Qian Wang,Jueqian Zhou,Liemin Zhou,Zi-yi Chen,Zi-yan Fang,Shuda Chen,Libai Yang,Xiao-dong Cai,Qi-lin Dai,Hua Hong,Hong-xuan Wang +10 more
TL;DR: The data showed that HLA-B*1502 allele is strongly associated with carbamazepine-induced SJS/TEN but not MPE in Han Chinese of southern China mainland.
Journal ArticleDOI
Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).
TL;DR: Investigation of the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus and their relationship with epileptogenesis found some expressional changes, which may provide new drug targets for development of new antiepileptic medicine.
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Pluronic P85-coated poly(butylcyanoacrylate) nanoparticles overcome phenytoin resistance in P-glycoprotein overexpressing rats with lithium-pilocarpine-induced chronic temporal lobe epilepsy
Zi-yan Fang,Shuda Chen,Jiaming Qin,Bao Chen,Guanzhong Ni,Ziyi Chen,Jueqian Zhou,Ze Li,Yuping Ning,Chuanbin Wu,Liemin Zhou +10 more
TL;DR: Pgp overexpression decreases therapeutic drug concentrations in the brains of subjects with drug-resistant epilepsy and P85-PHT-PBCA-NPs could increase these drug concentrations.
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Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy
Zhuojia Chen,Xueding Wang,Hong-sheng Wang,Shuda Chen,Liemin Zhou,Jiali Li,Wen-ying Shu,Jueqian Zhou,Zi-yan Fang,Yu Zhang,Min Huang +10 more
TL;DR: A rapid and specific high performance liquid chromatography-ultraviolet (HPLC-UV) method to simultaneously detect the concentrations of VPA and its major hepatotoxic metabolite 2-propyl-4-pentenoic acid (4-ene VPA) in human plasma has been established.
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STE20/SPS1-related proline/alanine-rich kinase is involved in plasticity of GABA signaling function in a mouse model of acquired epilepsy.
Libai Yang,Xiao-dong Cai,Jueqian Zhou,Shuda Chen,Yishu Chen,Ziyi Chen,Qian Wang,Zi-yan Fang,Liemin Zhou +8 more
TL;DR: The data suggests that SPAK is involved in the plasticity of GABA signaling function in acquired epilepsy via adjustment of [Cl-]i in hippocampal neurons.