Journal ArticleDOI
Long-term expressional changes of Na+ -K+ -Cl- co-transporter 1 (NKCC1) and K+ -Cl- co-transporter 2 (KCC2) in CA1 region of hippocampus following lithium-pilocarpine induced status epilepticus (PISE).
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TLDR
Investigation of the long-term expression profiles of NKCC1 and KCC2 in CA1 region in the mice model of lithium-pilocarpine induced status epilepticus and their relationship with epileptogenesis found some expressional changes, which may provide new drug targets for development of new antiepileptic medicine.About:
This article is published in Brain Research.The article was published on 2008-07-24. It has received 86 citations till now. The article focuses on the topics: Epileptogenesis & Status epilepticus.read more
Citations
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Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research
Wolfgang Löscher,Claudia Brandt +1 more
TL;DR: Two ongoing clinical trials will address the antiepileptogenic potential of topiramate and levetiracetam in patients with traumatic brain injury, hopefully translating laboratory discoveries into successful therapies.
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Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments.
TL;DR: This review shows that the antiepileptic effects of loop diuretics described in the pertinent literature are based on widely heterogeneous mechanisms ranging from actions on both neuronal NKCC1 and KCC2 to modulation of the brain extracellular volume fraction.
Journal ArticleDOI
GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity.
Massimo Avoli,Marco de Curtis +1 more
TL;DR: Experimental data that point at the paradoxical role played by GABA(A) receptor-mediated mechanisms in synchronizing neuronal networks, and in particular those of limbic structures such as the hippocampus, the entorhinal and perirhinal cortices, are reviewed.
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Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures
Volodymyr Dzhala,Kishore V. Kuchibhotla,Joseph Glykys,Kristopher T. Kahle,Waldemar Swiercz,Guoping Feng,Thomas Kuner,George J Augustine,Brian J. Bacskai,Kevin J. Staley +9 more
TL;DR: The results demonstrate a novel mechanism by which seizure activity leads to [Cl−]i accumulation, thereby increasing the probability of subsequent seizures, and provides a potential mechanism for the early crescendo phase of neonatal seizures.
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Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission.
TL;DR: The importance of post-translational mechanisms such as phosphorylation and dephosphorylation, oligomerization, cell surface stability, clustering and membrane diffusion for the rapid and dynamic regulation of KCC2 function is emphasized.
References
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Journal ArticleDOI
Excitatory actions of gaba during development: the nature of the nurture.
TL;DR: This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.
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The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
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Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TL;DR: In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges.
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GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
TL;DR: A novel role for amino acid neurotransmitters in regulating neocortical neurogenesis is found, and applied alone, GABAA and AMPA/kainate receptor antagonists increase DNA synthesis, indicating that endogenously released amino acids influence neocorticals progenitors in the cell cycle.
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NKCC1 transporter facilitates seizures in the developing brain
Volodymyr Dzhala,Delia M. Talos,Dan A Sdrulla,Audrey C. Brumback,Gregory C. Mathews,Tim A. Benke,Eric Delpire,Frances E. Jensen,Kevin J. Staley +8 more
TL;DR: Evidence that NKCC1 facilitates seizures in the developing brain is provided and indications that bumetanide should be useful in the treatment of neonatal seizures are indicated.