S
Shumin Gao
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 37
Citations - 3212
Shumin Gao is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Pressure overload & Heart failure. The author has an hindex of 23, co-authored 37 publications receiving 2911 citations. Previous affiliations of Shumin Gao include Rutgers University.
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Journal ArticleDOI
Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
Ralph R. Alcendor,Shumin Gao,Peiyong Zhai,Daniela Zablocki,Eric Holle,Xianzhong Yu,Bin Tian,Thomas E. Wagner,Stephen F. Vatner,Junichi Sadoshima +9 more
TL;DR: The results suggest that Sirt1 could retard aging and confer stress resistance to the heart in vivo, but these beneficial effects can be observed only at low to moderate doses (up to 7.5-fold) of Sirt 1.
Journal ArticleDOI
MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand
TL;DR: It is demonstrated here for the first time that miR-21 is positively regulated via an AKT-dependent pathway, which is depressed during prolonged hypoxia, and identified a unique aspect of the function of AKT by which it inhibits apoptosis through mi R-21-dependent suppression of FasL.
Reference EntryDOI
Echocardiography in Mice
TL;DR: The goal of this article is to provide a practical guide to the use of echo techniques in mice to evaluate cardiac systolic and diastolic function.
Journal ArticleDOI
Distinct roles of GSK-3α and GSK-3β phosphorylation in the heart under pressure overload
Takahisa Matsuda,Peiyong Zhai,Yasuhiro Maejima,Chull Hong,Shumin Gao,Bin Tian,Kazumichi Goto,Hiromitsu Takagi,Mimi Tamamori-Adachi,Shigetaka Kitajima,Junichi Sadoshima +10 more
TL;DR: S21 phosphorylation of GSK-3α plays a compensatory role during PO, in part by alleviating the negative constraint on the cell cycle machinery in cardiac myocytes, revealing its role in mediating cardiac hypertrophy and failure.
Journal ArticleDOI
Lats2 Is a Negative Regulator of Myocyte Size in the Heart
Yutaka Matsui,Noritsugu Nakano,Dan Shao,Shumin Gao,Wenting Luo,Chull Hong,Peiyong Zhai,Eric Holle,Xianzhong Yu,Norikazu Yabuta,Wufan Tao,Thomas E. Wagner,Hiroshi Nojima,Junichi Sadoshima +13 more
TL;DR: Lats2 affects both growth and death of cardiac myocytes, but it primarily regulates the size of the heart and acts as an endogenous negative regulator of cardiac hypertrophy, suggesting that endogenous Lats2 negatively regulates myocyte growth.