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Xianzhong Yu
Researcher at Clemson University
Publications - 64
Citations - 2580
Xianzhong Yu is an academic researcher from Clemson University. The author has contributed to research in topics: Fusion protein & Immune system. The author has an hindex of 19, co-authored 61 publications receiving 2355 citations. Previous affiliations of Xianzhong Yu include Jilin University & Greenville Health System.
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Journal ArticleDOI
Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
Ralph R. Alcendor,Shumin Gao,Peiyong Zhai,Daniela Zablocki,Eric Holle,Xianzhong Yu,Bin Tian,Thomas E. Wagner,Stephen F. Vatner,Junichi Sadoshima +9 more
TL;DR: The results suggest that Sirt1 could retard aging and confer stress resistance to the heart in vivo, but these beneficial effects can be observed only at low to moderate doses (up to 7.5-fold) of Sirt 1.
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Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Mitsutaka Yamamoto,Guiping Yang,Chull Hong,Jing Liu,Eric Holle,Xianzhong Yu,Thomas E. Wagner,Stephen F. Vatner,Junichi Sadoshima +8 more
TL;DR: It is demonstrated that endogenous Trx1 is an essential component of the cellular antioxidant mechanisms and plays a critical role in regulating oxidative stress in the heart in vivo and inhibits hypertrophy, both under basal conditions and in response to pressure overload through redox-sensitive mechanisms.
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Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice
Peiyong Zhai,Mitsutaka Yamamoto,Jonathan Galeotti,Jing Liu,Malthi Masurekar,Jill Thaisz,Keiichi Irie,Eric Holle,Xianzhong Yu,Sabina Kupershmidt,Dan M. Roden,Thomas Wagner,Atsuko Yatani,Dorothy E. Vatner,Stephen F. Vatner,Junichi Sadoshima +15 more
TL;DR: The AT1 receptor mediates downstream signaling mechanisms through G( alpha)q/G(alpha)i-dependent and -independent mechanisms, which induce hypertrophy with a distinct phenotype in Tg-i2m mice.
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Lats2 Is a Negative Regulator of Myocyte Size in the Heart
Yutaka Matsui,Noritsugu Nakano,Dan Shao,Shumin Gao,Wenting Luo,Chull Hong,Peiyong Zhai,Eric Holle,Xianzhong Yu,Norikazu Yabuta,Wufan Tao,Thomas E. Wagner,Hiroshi Nojima,Junichi Sadoshima +13 more
TL;DR: Lats2 affects both growth and death of cardiac myocytes, but it primarily regulates the size of the heart and acts as an endogenous negative regulator of cardiac hypertrophy, suggesting that endogenous Lats2 negatively regulates myocyte growth.
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An Angiotensin II Type 1 Receptor Mutant Lacking Epidermal Growth Factor Receptor Transactivation Does Not Induce Angiotensin II–Mediated Cardiac Hypertrophy
Peiyong Zhai,Jonathan Galeotti,Jing Liu,Eric Holle,Xianzhong Yu,Thomas E. Wagner,Junichi Sadoshima +6 more
TL;DR: In conclusion, overexpression of AT1-Y319F in cardiac myocytes diminished EGFR transactivation and inhibited a pathological form of cardiac hypertrophy, indicating that the YIPP motif in the AT1R plays an important role in mediating cardiachypertrophy in vivo.