Z
Zhi Yang
Researcher at Rutgers University
Publications - 15
Citations - 569
Zhi Yang is an academic researcher from Rutgers University. The author has contributed to research in topics: Gene expression & Gene knockdown. The author has an hindex of 6, co-authored 12 publications receiving 470 citations. Previous affiliations of Zhi Yang include University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand
TL;DR: It is demonstrated here for the first time that miR-21 is positively regulated via an AKT-dependent pathway, which is depressed during prolonged hypoxia, and identified a unique aspect of the function of AKT by which it inhibits apoptosis through mi R-21-dependent suppression of FasL.
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GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy
Mingyue Han,Zhi Yang,Danish Sayed,Minzhen He,Shumin Gao,Lin Lin,Seong Hun Yoon,Maha Abdellatif +7 more
TL;DR: Down- regulation of miR-26b in the heart is required for the up-regulation of GATA4 and the induction of pressure-induced cardiac hypertrophy and underscores the functional relevance of miRNAs in regulating gene expression during cardiac hyperTrophy.
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Transcriptional regulation patterns revealed by high resolution chromatin immunoprecipitation during cardiac hypertrophy.
TL;DR: The results demonstrate that promoter-paused pol II plays a role in incrementally increasing housekeeping genes, proportionate to the increase in heart size, underscoring the significance of posttranscriptional regulation by miRNA.
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Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure
Michinari Nakamura,Natalija Odanovic,Yasuki Nakada,Satomi Dohi,Peiyong Zhai,Andreas S. Ivessa,Zhi Yang,Maha Abdellatif,Junichi Sadoshima +8 more
TL;DR: It is demonstrated that strict restriction of dietary carbohydrates supplemented with either fat or proteins during acute hemodynamic stress attenuates the development and progression of cardiac hypertrophy and heart failure by activating distinct anti-hypertrophic and cardioprotective signaling mechanisms.
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GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy.
TL;DR: G3bp1 posttranscriptionally regulates miRNA-1 processing in the heart, and G3BP1 mediated downregulation of mature mi RNA-1 levels is required for the derepression of its targets and increase in gene expression during cardiac hypertrophy.