S
Shunmoogum A. Patten
Researcher at Institut national de la recherche scientifique
Publications - 33
Citations - 923
Shunmoogum A. Patten is an academic researcher from Institut national de la recherche scientifique. The author has contributed to research in topics: Chemistry & In vivo. The author has an hindex of 13, co-authored 27 publications receiving 676 citations. Previous affiliations of Shunmoogum A. Patten include Université du Québec & Université de Montréal.
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Journal ArticleDOI
Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo.
Alexandra Vaccaro,Shunmoogum A. Patten,Dina Aggad,Carl Julien,Claudia Maios,Edor Kabashi,Pierre Drapeau,J. Alex Parker +7 more
TL;DR: The results indicate that protein-folding homeostasis in the ER is an important target for therapeutic development in ALS and other TDP-43-related neurodegenerative diseases.
Journal ArticleDOI
RNA Dysregulation in Amyotrophic Lateral Sclerosis.
Zoé Butti,Shunmoogum A. Patten +1 more
TL;DR: The current understanding of RNA dysregulation in ALS pathogenesis involving these major ALS genes is highlighted and the potential of therapeutic strategies targeting disease RNAs for treating ALS is discussed.
Journal ArticleDOI
Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio
Alexandra Vaccaro,Shunmoogum A. Patten,Sorana Ciura,Claudia Maios,Martine Therrien,Pierre Drapeau,Edor Kabashi,J. Alex Parker +7 more
TL;DR: It is found that methylene blue can rescue toxic phenotypes associated with mutant TDP-43 and FUS including neuronal dysfunction and oxidative stress, and three compounds with potential neuroprotective properties were tested: lithium chloride, methyleneblue and riluzole.
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Functional variants of POC5 identified in patients with idiopathic scoliosis
Shunmoogum A. Patten,Patricia Margaritte-Jeannin,Jean-Claude Bernard,Eudeline Alix,Audrey Labalme,Alicia Besson,Simon Girard,Khaled Fendri,Nicolas Fraisse,Bernard Biot,Coline Poizat,Amandine Campan-Fournier,Kariman Abelin-Genevois,Vincent Cunin,Charlotte Zaouter,Meijiang Liao,Raphaelle Lamy,Gaetan Lesca,Rita Menassa,Charles Marcaillou,Melanie Letexier,Damien Sanlaville,Jérôme Berard,Guy A. Rouleau,Françoise Clerget-Darpoux,Pierre Drapeau,Florina Moldovan,Patrick Edery +27 more
TL;DR: Findings indicate that mutations in the POC5 gene contribute to the occurrence of IS, and expression of any of the 3 human IS-associated POC 5 variant mRNAs resulted in spine deformity, without affecting other skeletal structures.
Journal ArticleDOI
Role of Chd7 in zebrafish: a model for CHARGE syndrome.
Shunmoogum A. Patten,Nicole L. Jacobs-McDaniels,Charlotte Zaouter,Pierre Drapeau,R. Craig Albertson,R. Craig Albertson,Florina Moldovan +6 more
TL;DR: It is shown that Chd7 is required for the organization of the neural retina in zebrafish and an abnormal expression or a complete absence of molecular markers for the retinal ganglion cells and photoreceptors are observed, indicating that ChD7 regulates the differentiation of retinal cells and plays an essential role in retinal cell development.