S
Simon Girard
Researcher at Université du Québec à Chicoutimi
Publications - 74
Citations - 3950
Simon Girard is an academic researcher from Université du Québec à Chicoutimi. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 29, co-authored 65 publications receiving 3362 citations. Previous affiliations of Simon Girard include McGill University & Montreal Neurological Institute and Hospital.
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Journal ArticleDOI
Increased exonic de novo mutation rate in individuals with schizophrenia
Simon Girard,Julie Gauthier,Anne Noreau,Lan Xiong,Sirui Zhou,Loubna Jouan,Alexandre Dionne-Laporte,Dan Spiegelman,Edouard Henrion,Ousmane Diallo,Pascale Thibodeau,Isabelle Bachand,Jessie Y.J. Bao,Amy Hin Yan Tong,Chi-Ho Lin,Bruno Millet,Bruno Millet,Nematollah Jaafari,Nematollah Jaafari,Ridha Joober,Patrick A. Dion,Si Lok,Marie-Odile Krebs,Guy A. Rouleau,Guy A. Rouleau +24 more
TL;DR: This study sequenced the exomes of 14 schizophrenia probands and their parents to identify 15 de novo mutations (DNMs) in eight probands, which is significantly more than expected considering the previously reported DNM rate.
Journal ArticleDOI
Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
Lea K. Davis,Dongmei Yu,Clare L. Keenan,Eric R. Gamazon,Anuar Konkashbaev,Eske M. Derks,Benjamin M. Neale,Jian Yang,S. Hong Lee,Patrick Evans,Cathy L. Barr,Laura Bellodi,Fortu Benarroch,Gabriel Bedoya Berrío,Oscar J. Bienvenu,Michael H. Bloch,Rianne M. Blom,Ruth D. Bruun,Cathy L. Budman,Beatriz Camarena,Desmond Campbell,Carolina Cappi,Julio C. Cardona Silgado,Danielle C. Cath,Maria Cristina Cavallini,Denise A. Chavira,Sylvain Chouinard,David V. Conti,Edwin H. Cook,Vladimir Coric,Bernadette Cullen,Dieter Deforce,Richard Delorme,Yves Dion,Christopher K. Edlund,Karin Egberts,Peter Falkai,Thomas V. Fernandez,Patience J. Gallagher,Helena Garrido,Daniel A. Geller,Simon Girard,Hans J. Grabe,Marco A. Grados,Benjamin D. Greenberg,Varda Gross-Tsur,Stephen A. Haddad,Gary A. Heiman,Sian M. J. Hemmings,Ana Gabriela Hounie,Cornelia Illmann,Joseph Jankovic,Michael A. Jenike,James L. Kennedy,Robert A. King,Barbara Kremeyer,R. Kurlan,Nuria Lanzagorta,Marion Leboyer,James F. Leckman,Leonhard Lennertz,Chunyu Liu,Christine Lochner,Thomas L. Lowe,Fabio Macciardi,James T. McCracken,Lauren M. McGrath,Sandra Catalina Mesa Restrepo,Rainald Moessner,Jubel Morgan,H. Müller,Dennis L. Murphy,Allan L. Naarden,William Cornejo Ochoa,Roel A. Ophoff,Lisa Osiecki,Andrew J. Pakstis,Michele T. Pato,Carlos N. Pato,John Piacentini,Christopher Pittenger,Yehuda Pollak,Scott L. Rauch,Tobias J. Renner,Victor I. Reus,Margaret A. Richter,Mark A. Riddle,Mary M. Robertson,Roxana Romero,Maria Conceição do Rosário,David R. Rosenberg,Guy A. Rouleau,Stephan Ruhrmann,Andres Ruiz-Linares,Aline S. Sampaio,Jack Samuels,Paul Sandor,Brooke Sheppard,Harvey S. Singer,Jan Smit,Dan J. Stein,Eric Strengman,Jay A. Tischfield,Ana V. Valencia Duarte,Homero Vallada,Filip Van Nieuwerburgh,Jeremy Veenstra-VanderWeele,Susanne Walitza,Ying Wang,Jens R. Wendland,H.G.M. Westenberg,Yin Yao Shugart,Euripedes Constantino Miguel,William M. McMahon,Michael Wagner,Humberto Nicolini,Danielle Posthuma,Gregory L. Hanna,Peter Heutink,Damiaan Denys,Paul D. Arnold,Ben A. Oostra,Gerald Nestadt,Nelson B. Freimer,David L. Pauls,Naomi R. Wray,S. Evelyn Stewart,Carol A. Mathews,James A. Knowles,Nancy J. Cox,Jeremiah M. Scharf +130 more
TL;DR: The results indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.
Journal ArticleDOI
Audio-visual integration of emotion expression.
Olivier Collignon,Simon Girard,Frédéric Gosselin,Sylvain Roy,Dave Saint-Amour,Maryse Lassonde,Franco Lepore +6 more
TL;DR: Results of three experiments on multisensory perception of emotions using newly validated sets of dynamic visual and non-linguistic vocal clips of affect expressions indicate that the perception of emotion expressions is a robust multisENSory situation which follows rules that have been previously observed in other perceptual domains.
Journal ArticleDOI
High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies
Fadi F. Hamdan,Candace T. Myers,Patrick Cossette,Philippe Lemay,Dan Spiegelman,Alexandre D. Laporte,Christina Nassif,Ousmane Diallo,Jean Monlong,Maxime Cadieux-Dion,Maxime Cadieux-Dion,Sylvia Dobrzeniecka,Caroline Meloche,Kyle Retterer,Megan T. Cho,Jill A. Rosenfeld,Weimin Bi,Christine Massicotte,Marguerite Miguet,Ledia Brunga,Brigid M. Regan,Kelly Mo,Cory Tam,Amy L Schneider,Georgie Hollingsworth,David R. FitzPatrick,Alan Donaldson,Natalie Canham,Edward Blair,Bronwyn Kerr,Andrew E. Fry,Rhys H. Thomas,Joss Shelagh,Jane A. Hurst,Helen Brittain,Moira Blyth,Robert Roger Lebel,Erica H. Gerkes,Laura Davis-Keppen,Quinn Stein,Wendy K. Chung,Sara J. Dorison,Paul J. Benke,Emily Fassi,Nicole Corsten-Janssen,Erik-Jan Kamsteeg,Frédéric Tran Mau-Them,Ange-Line Bruel,Alain Verloes,Katrin Õunap,Monica H. Wojcik,Monica H. Wojcik,Dara V.F. Albert,Sunita Venkateswaran,Tyson L Ware,D. L. Jones,Yu Chi Liu,Yu Chi Liu,Shekeeb S. Mohammad,Peyman Bizargity,Carlos A. Bacino,Carlos A. Bacino,Vincenzo Leuzzi,Simone Martinelli,Bruno Dallapiccola,Marco Tartaglia,Lubov Blumkin,Klaas J. Wierenga,Gabriela Purcarin,James J. O'Byrne,Sylvia Stockler,Anna Lehman,Boris Keren,Marie-Christine Nougues,Cyril Mignot,Stéphane Auvin,Caroline Nava,Susan M. Hiatt,Martina Bebin,Yunru Shao,Fernando Scaglia,Seema R. Lalani,Richard E. Frye,Imad Jarjour,Stéphanie Jacques,Renee-Myriam Boucher,Emilie Riou,Myriam Srour,Lionel Carmant,Lionel Carmant,Anne Lortie,Philippe Major,Paola Diadori,François Dubeau,Guy D'Anjou,Guillaume Bourque,Samuel F. Berkovic,Lynette G. Sadleir,Philippe M. Campeau,Philippe M. Campeau,Zoha Kibar,Zoha Kibar,Ronald G. Lafrenière,Simon Girard,Simon Girard,Simon Girard,Saadet Mercimek-Mahmutoglu,Cyrus Boelman,Guy A. Rouleau,Ingrid E. Scheffer,Ingrid E. Scheffer,Ingrid E. Scheffer,Heather C Mefford,Danielle M. Andrade,Elsa Rossignol,Elsa Rossignol,Berge A. Minassian,Berge A. Minassian,Jacques L. Michaud,Jacques L. Michaud +119 more
TL;DR: De novo missense variants explained a larger proportion of individuals in the series than in other series that were primarily ascertained because of ID, indicating that the genetic landscape of DEE might be different from that of ID without epilepsy.
Journal ArticleDOI
Exome Sequencing Identifies FUS Mutations as a Cause of Essential Tremor
Nancy D. Merner,Simon Girard,Hélène Catoire,Cynthia V. Bourassa,Veronique V. Belzil,Jean-Baptiste Rivière,Pascale Hince,Annie Levert,Alexandre Dionne-Laporte,Dan Spiegelman,Anne Noreau,Sabrina Diab,Anna Szuto,Helene Fournier,John Verner Raelson,Majid Belouchi,Michel Panisset,Patrick Cossette,Nicolas Dupré,Geneviève Bernard,Sylvain Chouinard,Patrick A. Dion,Guy A. Rouleau +22 more
TL;DR: Exome sequencing is used to implement a simple approach to control for misdiagnosis of ET, as well as phenocopies involving sporadic and senile ET cases, and it is shown that the ET FUS nonsense mutation is degraded by the nonsense-mediated-decay pathway, whereas amyotrophic lateral sclerosis FUS mutant transcripts are not.