M
Martine Therrien
Researcher at Broad Institute
Publications - 18
Citations - 635
Martine Therrien is an academic researcher from Broad Institute. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 9, co-authored 13 publications receiving 468 citations. Previous affiliations of Martine Therrien include Picower Institute for Learning and Memory & Université de Montréal.
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Journal ArticleDOI
Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegans.
TL;DR: A genetic model of ALS is generated to explore the biological consequences of a null mutation of the Caenorhabditis elegans C9ORF72 orthologue, F18A1.6, and it is observed that the motor defects caused by loss of alfa-1 were additive with the toxicity caused by mutant TDP-43 proteins, but not by the mutant FUS proteins.
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Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
Hyeseung Lee,Robert J. Fenster,S. Sebastian Pineda,Whitney S. Gibbs,Shahin Mohammadi,Jose Davila-Velderrain,Jose Davila-Velderrain,Francisco J. Garcia,Martine Therrien,Martine Therrien,Hailey S. Novis,Fan Gao,Hilary Wilkinson,Thomas F. Vogt,Manolis Kellis,Manolis Kellis,Matthew J. LaVoie,Myriam Heiman,Myriam Heiman,Myriam Heiman +19 more
TL;DR: It is revealed that the activation of innate immune signaling in the most vulnerable HD neurons provides a novel framework to understand the basis of mHTT toxicity and raises new therapeutic opportunities.
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Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio
Alexandra Vaccaro,Shunmoogum A. Patten,Sorana Ciura,Claudia Maios,Martine Therrien,Pierre Drapeau,Edor Kabashi,J. Alex Parker +7 more
TL;DR: It is found that methylene blue can rescue toxic phenotypes associated with mutant TDP-43 and FUS including neuronal dysfunction and oxidative stress, and three compounds with potential neuroprotective properties were tested: lithium chloride, methyleneblue and riluzole.
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Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.
Mary H. Wertz,Mary H. Wertz,Mollie R. Mitchem,Mollie R. Mitchem,S. Sebastian Pineda,S. Sebastian Pineda,Lea J. Hachigian,Lea J. Hachigian,Lea J. Hachigian,Hyeseung Lee,Hyeseung Lee,Vanessa Lau,Vanessa Lau,Alex Powers,Alex Powers,Ruth Kulicke,Ruth Kulicke,Gurrein K. Madan,Medina Colic,Martine Therrien,Martine Therrien,Amanda Vernon,Amanda Vernon,Amanda Vernon,Victoria F. Beja-Glasser,Victoria F. Beja-Glasser,Victoria F. Beja-Glasser,Mudra Hegde,Fan Gao,Fan Gao,Manolis Kellis,Manolis Kellis,Traver Hart,John G. Doench,Myriam Heiman,Myriam Heiman,Myriam Heiman +36 more
TL;DR: The first genome-wide genetic screens in the mammalian central nervous system using both short hairpin RNA (shRNA) and CRISPR libraries are reported, revealing a molecular logic for the common implication of these pathways across multiple neurodegenerative diseases.
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ALS: Recent Developments from Genetics Studies
TL;DR: It is interesting to note that as the number of ALS genes grows, many of the proteins they encode are in shared intracellular processes.