S
Shuomin Zhu
Researcher at Southern Illinois University School of Medicine
Publications - 4
Citations - 3832
Shuomin Zhu is an academic researcher from Southern Illinois University School of Medicine. The author has contributed to research in topics: Gene silencing & microRNA. The author has an hindex of 4, co-authored 4 publications receiving 3673 citations.
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miR-21-mediated tumor growth
TL;DR: The results suggest that miR-21 functions as an oncogene and modulates tumorigenesis through regulation of genes such as bcl-2 and thus, it may serve as a novel therapeutic target.
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MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
TL;DR: Two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-mir-21 and identified the tumor suppressor tropomyosin 1 (TPM1) as a potential mir-21 target found that down-regulation of TPM1 by mir- 21 may explain, at least in part, why suppression of mir-23 can inhibit tumor growth, further supporting the notion that mir-20 functions as an oncogene.
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MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
TL;DR: In this article, the role of mir-21 in cell invasion and tumor metastasis was investigated in metastatic breast cancer MDA-MB-231 cells, and it was shown that suppressing the expression of the tumor suppressor gene tropomyosin 1 (TPM1) significantly reduced cell invasion.
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Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner
TL;DR: It is shown that ectopic expression of wild-type Ubc9 (Ubc9-WT) promotes cell invasion and metastasis, and that suppression of CDC42 and CXCR4 by RNAi causes inhibition of Ubc 9-mediated invasion.