H
Hailong Wu
Researcher at Southern Illinois University School of Medicine
Publications - 18
Citations - 5186
Hailong Wu is an academic researcher from Southern Illinois University School of Medicine. The author has contributed to research in topics: Gene silencing & microRNA. The author has an hindex of 10, co-authored 12 publications receiving 4942 citations.
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Journal ArticleDOI
miR-21-mediated tumor growth
TL;DR: The results suggest that miR-21 functions as an oncogene and modulates tumorigenesis through regulation of genes such as bcl-2 and thus, it may serve as a novel therapeutic target.
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MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1)
TL;DR: Two-dimensional differentiation in-gel electrophoresis of tumors treated with anti-mir-21 and identified the tumor suppressor tropomyosin 1 (TPM1) as a potential mir-21 target found that down-regulation of TPM1 by mir- 21 may explain, at least in part, why suppression of mir-23 can inhibit tumor growth, further supporting the notion that mir-20 functions as an oncogene.
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MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
TL;DR: In this article, the role of mir-21 in cell invasion and tumor metastasis was investigated in metastatic breast cancer MDA-MB-231 cells, and it was shown that suppressing the expression of the tumor suppressor gene tropomyosin 1 (TPM1) significantly reduced cell invasion.
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p53 represses c-Myc through induction of the tumor suppressor miR-145
Mohit Sachdeva,Shoumin Zhu,Fangting Wu,Hailong Wu,Vijay Walia,Sumit Kumar,Randolph C. Elble,Kounosuke Watabe,Yin-Yuan Mo +8 more
TL;DR: The role of miR-145 is defined in the posttranscriptional regulation of c-Myc by p53 and it is suggested that, as a new member of the p53 regulatory network, mi R-145 provides a direct link between p 53 and c- myc in this gene regulatory network.
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Suppression of cell growth and invasion by miR-205 in breast cancer
TL;DR: It is reported that miR-205 is significantly underexpressed in breast tumor compared to the matched normal breast tissue, and western blot combined with the luciferase reporter assays demonstrate that ErbB3 and vascular endothelial growth factor A (VEGF-A) are direct targets for miR.