S
Shuzhen Sim
Researcher at Johns Hopkins University
Publications - 30
Citations - 2254
Shuzhen Sim is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Dengue virus & Aedes aegypti. The author has an hindex of 17, co-authored 24 publications receiving 1890 citations. Previous affiliations of Shuzhen Sim include National Environment Agency & Genome Institute of Singapore.
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An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense
TL;DR: The data suggest that the JAK-STAT pathway is part of the A. aegypti mosquito's anti-dengue defense and may act independently of the Toll pathway and the RNAi-mediated antiviral defenses.
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Dengue virus infection of the Aedes aegypti salivary gland and chemosensory apparatus induces genes that modulate infection and blood-feeding behavior.
TL;DR: It is shown for the first time that the mosquito salivary gland mounts responses to suppress DENV which, in turn, modulates the expression of chemosensory-related genes that regulate feeding behavior and may have the potential to affect DENV transmission between humans.
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Mosquito immune defenses against Plasmodium infection.
TL;DR: Recent findings on the role of the mosquito's innate immune signaling pathways in preventing infection by the Plasmodium parasite, the identification and mechanistic description of novel anti-parasite molecules, the role that natural bacteria harbored in the mosquito midgut might play in this immune defense and the crucial parasite and vector molecules that mediate midGut infection are discussed.
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Transcriptomic Profiling of Diverse Aedes aegypti Strains Reveals Increased Basal-level Immune Activation in Dengue Virus-refractory Populations and Identifies Novel Virus-vector Molecular Interactions
Shuzhen Sim,Natapong Jupatanakul,Jose Luis Ramirez,Seokyoung Kang,Claudia M. E. Romero-Vivas,Hamish Mohammed,George Dimopoulos +6 more
TL;DR: The comparative transcriptome dataset not only provides valuable information about immune gene regulation and usage in natural refractoriness of mosquito populations to dengue virus but also allows us to identify new molecular interactions between the virus and its mosquito vector.
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The insect microbiome modulates vector competence for arboviruses.
TL;DR: Studying the interactions between insect vectors and their microbiota is an important step toward developing alternative strategies for arbovirus transmission control.