S
Shyh-Han Tan
Researcher at Uniformed Services University of the Health Sciences
Publications - 57
Citations - 2899
Shyh-Han Tan is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Prostate cancer & Erg. The author has an hindex of 23, co-authored 48 publications receiving 2691 citations. Previous affiliations of Shyh-Han Tan include Walter Reed National Military Medical Center & Institute of Molecular and Cell Biology.
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Journal ArticleDOI
ERG transcription factor as an immunohistochemical marker for vascular endothelial tumors and prostatic carcinoma.
Markku Miettinen,Zengfeng Wang,Anders Paetau,Shyh-Han Tan,Albert Dobi,Shiv Srivastava,Isabell A. Sesterhenn +6 more
TL;DR: Among epithelial tumors, ERG shows a great promise as a marker to identify prostatic carcinoma in both primary and metastatic settings, and is a highly specific new marker for benign and malignant vascular tumors.
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SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles
TL;DR: It is found that RanGAP1 associates with mitotic spindles and that it is particularly concentrated at foci near kinetochores, suggesting that a complex between these two proteins may be involved in mitotic targeting of RanG AP1.
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TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.
Chen Sun,Albert Dobi,Ahmed A. Mohamed,Hongzhen Li,Rajesh L. Thangapazham,Bungo Furusato,Bungo Furusato,Syed Shaheduzzaman,Shyh-Han Tan,Ganesan Vaidyanathan,Eric J. Whitman,Eric J. Whitman,D. J. Hawksworth,D. J. Hawksworth,Yongmei Chen,Martin E. Nau,Vyomesh Patel,Maryanne Vahey,Jorge S. Gutkind,Taduru Sreenath,Gyorgy Petrovics,Isabell A. Sesterhenn,David G. McLeod,David G. McLeod,Shiv Srivastava +24 more
TL;DR: Evaluation of the transcriptome and specific gene promoters in ERG siRNA-treated cells and investigation of gene expression signatures of human prostate tumors revealed ERG-mediated activation of C-MYC oncogene and the repression of prostate epithelial differentiation genes (PSA and SLC45A3/Prostein).
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ERG oncoprotein expression in prostate cancer: clonal progression of ERG-positive tumor cells and potential for ERG-based stratification
Bungo Furusato,Shyh-Han Tan,Denise Y. Young,Albert Dobi,Chen Sun,Ahmed A. Mohamed,Rajesh L. Thangapazham,Yongmei Chen,Gary K. McMaster,Taduru Sreenath,Gyorgy Petrovics,David G. McLeod,David G. McLeod,Shiv Srivastava,Isabell A. Sesterhenn +14 more
TL;DR: The homogeneous and strong ERG expression detected in individual tumors establishes the potential for ERG oncoprotein-based stratification of CaP and confirms the biological role of ERG in clonal selection of prostate tumors in 65% of patients.
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The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID.
TL;DR: It is concluded that each of the E2 binding sites in the E6 promoter of genital human papillomaviruses plays a separate role by displacing the transcription factors Sp1 and TFIID.