S
Sigrun Thorsdottir
Researcher at Karolinska Institutet
Publications - 7
Citations - 59
Sigrun Thorsdottir is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Pneumolysin & Medicine. The author has an hindex of 2, co-authored 4 publications receiving 25 citations. Previous affiliations of Sigrun Thorsdottir include Karolinska University Hospital.
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Journal ArticleDOI
The role of microglia in bacterial meningitis : inflammatory response, experimental models and new neuroprotective therapeutic strategies
Sigrun Thorsdottir,Birgitta Henriques-Normark,Birgitta Henriques-Normark,Birgitta Henriques-Normark,Federico Iovino,Federico Iovino +5 more
TL;DR: An overview on how microglia respond to bacterial pathogens targeting the brain, how the interplay betweenmicroglia and bacteria can be studied experimentally, and possible ways to use gained knowledge to identify novel preventive and therapeutic strategies are provided.
Journal ArticleDOI
Receptor Blockade: A Novel Approach to Protect the Brain From Pneumococcal Invasion.
Federico Iovino,Federico Iovino,Sigrun Thorsdottir,Sigrun Thorsdottir,Birgitta Henriques-Normark,Birgitta Henriques-Normark,Birgitta Henriques-Normark +6 more
TL;DR: In this paper, the authors suggest that adjunct treatment with pIgR and PECAM-1 antibodies to antibiotics may prevent pneumococcal meningitis development and associated brain damages.
Journal ArticleDOI
Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin
Mahebali Tabusi,Mahebali Tabusi,Sigrun Thorsdottir,Sigrun Thorsdottir,Maria Lysandrou,Maria Lysandrou,Ana Rita Narciso,Ana Rita Narciso,Melania Minoia,Chinmaya Venugopal Srambickal,Jerker Widengren,Birgitta Henriques-Normark,Birgitta Henriques-Normark,Federico Iovino,Federico Iovino +14 more
TL;DR: This article showed that pneumococcus pneumoniae (pneumococcus) is a leading cause of bacterial meningitis and many survivors develop neurological sequelae after the acute infection has resolved, possibly due to neuronal damage.
Journal ArticleDOI
Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis
Jaqueline S. Generoso,Sigrun Thorsdottir,Allan Collodel,Diogo Dominguini,Roberta R. E. Santo,Fabricia Petronilho,Tatiana Barichello,Federico Iovino +7 more
TL;DR: The results clearly showed that during pneumococcal meningitis, the glymphatic system does not function because of a detachment of the astrocytic end feet from the blood-brain barrier (BBB) vascular endothelium, which leads to misplacement of AQP4 with the consequent loss of the AQP 4 water channel's functionality.
Journal ArticleDOI
Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA
Ana Rita Narciso,Federico Iovino,Sigrun Thorsdottir,Peter Mellroth,Mario Codemo,Christian Spoerry,Francesco Righetti,Sandra Muschiol,Staffan Normark,Priyanka Nannapaneni,Birgitta Henriques-Normark +10 more
TL;DR: Pneumococcal membrane particles (MPs) evoke a serotype-independent cross-protection against IPD, dependent on the presence of the two conserved lipoproteins MalX and PrsA, and it is suggested that MPs can be used for pneumococcal vaccine development.