F
Federico Iovino
Researcher at Karolinska Institutet
Publications - 30
Citations - 589
Federico Iovino is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Streptococcus pneumoniae & Meningitis. The author has an hindex of 12, co-authored 26 publications receiving 440 citations. Previous affiliations of Federico Iovino include University Medical Center Groningen & Karolinska University Hospital.
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Journal ArticleDOI
pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.
Federico Iovino,Federico Iovino,Joo-Yeon Engelen-Lee,Matthijs C. Brouwer,Diederik van de Beek,Arie van der Ende,Merche Valls Seron,Peter Mellroth,Peter Mellroth,Sandra Muschiol,Sandra Muschiol,Jan Bergstrand,Jerker Widengren,Birgitta Henriques-Normark +13 more
TL;DR: Inhibition of pIgR and PECAM-1 has the potential to prevent pneumococcal meningitis, and adding antibodies to antibiotic-treated mice further reduce the bacterial burden in the brain.
Journal ArticleDOI
Interactions between Blood-Borne Streptococcus pneumoniae and the Blood-Brain Barrier Preceding Meningitis
TL;DR: The results imply that the local immune system of the brain is activated immediately upon entry of bacteria into the bloodstream and that adhesion to the blood brain barrier is spatiotemporally controlled at different sites throughout the brain.
Journal ArticleDOI
Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses
Mario Codemo,Sandra Muschiol,Federico Iovino,Priyanka Nannapaneni,Laura Plant,Sun Nyunt Wai,Birgitta Henriques-Normark,Birgitta Henriques-Normark +7 more
TL;DR: The data suggest that EVs may act in an immunomodulatory manner by allowing delivery of vesicle-associated proteins and other macromolecules into host cells and help pneumococci to avoid complement deposition and phagocytosis-mediated killing, thereby possibly contributing to the symptoms found in pneumococcal infections.
Journal ArticleDOI
How Does Streptococcus pneumoniae Invade the Brain
Federico Iovino,Federico Iovino,Jolien Seinen,Birgitta Henriques-Normark,Birgitta Henriques-Normark,Jan Maarten van Dijl +5 more
TL;DR: It is suggested that, by precisely defining the pathways and ligands by which S. pneumoniae adheres to specific receptors, it may be possible to interfere with the respective mechanisms and develop strategies to prevent or even cure pneumococcal meningitis.
Journal ArticleDOI
Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease
TL;DR: The role of platelet activation factor receptor (PAFR) in invasive pneumococcal disease has been discussed in this article, with the potential to enable the development of novel therapeutic strategies for treating pneumonia by interfering with the PAFR.