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Sijia Li
Researcher at Central South University
Publications - 8
Citations - 139
Sijia Li is an academic researcher from Central South University. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 3, co-authored 4 publications receiving 40 citations.
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Journal ArticleDOI
Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2.
Ashuai Du,Rong Zheng,Cyrollah Disoma,Shiqin Li,Zongpeng Chen,Sijia Li,Pinjia Liu,Yuzheng Zhou,Yilun Shen,Sixu Liu,Yongxing Zhang,Zijun Dong,Qinglong Yang,Moyed Alsaadawe,Aroona Razzaq,Yuyang Peng,Xuan Chen,Liqiang Hu,Jian Peng,Qianjun Zhang,Taijiao Jiang,Long Mo,Shanni Li,Zanxian Xia +23 more
TL;DR: Wang et al. as mentioned in this paper reported that epigallocatechin-3-gallate (EGCG), an active ingredient of Chinese herbal medicine (CHM), is a potent inhibitor of 3CLpro with half-maximum inhibitory concentration (IC50) of 0.874± 0.005μM.
Journal ArticleDOI
SARS-CoV-2: Mechanism of infection and emerging technologies for future prospects
Shiqin Li,Sijia Li,Cyrollah Disoma,Rong Zheng,Mei Zhou,Aroona Razzaq,Pinjia Liu,Yuzheng Zhou,Yuzheng Zhou,Zijun Dong,Ashuai Du,Jian Peng,Liqiang Hu,Jufang Huang,Pinghui Feng,Taijiao Jiang,Zanxian Xia +16 more
TL;DR: The application of PROteolysis TArgeting Chimeras strategy, CRISPR‐Cas9 gene editing technology, and Single‐Nucleotide‐Specific Programmable Riboregulators technology in developing antiviral drugs and detecting infectious diseases are proposed here.
Journal ArticleDOI
Microbiome Profiling Using Shotgun Metagenomic Sequencing Identified Unique Microorganisms in COVID-19 Patients With Altered Gut Microbiota.
Sijia Li,Siyuan Yang,Yuzheng Zhou,Cyrollah Disoma,Zijun Dong,Ashuai Du,Yongxing Zhang,Yong Chen,Weiliang Huang,Junru Chen,Deqiang Song,Zongpeng Chen,Pinjia Liu,Shiqin Li,Rong Zheng,Sixu Liu,Aroona Razzaq,Xuan Chen,Siyi Tao,Chengping Yu,Tianxu Feng,Wenyan Liao,Yousong Peng,Taijiao Jiang,Jufang Huang,Wei Wu,Liqiang Hu,Linghang Wang,Shanni Li,Zanxian Xia +29 more
TL;DR: Wang et al. as discussed by the authors used shotgun metagenomic sequencing to identify four microorganisms unique in COVID-19 patients, namely Streptococcus thermophilus, Bacteroides oleiciplenus, Fusobacterium ulcerans, and Prevotella bivia.
Journal ArticleDOI
Protein interactome of the deamidase phosphoribosylformylglycinamidine synthetase (PFAS) by LC-MS/MS.
Ai Lu,Cyrollah Disoma,Yuzheng Zhou,Zongpeng Chen,Liming Zhang,Yilun Shen,Mei Zhou,Ashuai Du,Rong Zheng,Sijia Li,Moyed Alsaadawe,Shiqin Li,Jia-Da Li,Weilan Wang,Taijiao Jiang,Jian Peng,Zanxian Xia +16 more
TL;DR: It is shown here that PFAS is able to deamidate PHGDH, and induce other posttranslational modification into CAD, CCT2 and PRDX1.
Journal ArticleDOI
Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation
Yucheng Zhou,Rong Zheng,Sixu Liu,Cyrollah Disoma,Ashuai Du,Shiqin Li,Zongpeng Chen,Zijun Dong,Yongxing Zhang,Sijia Li,Pinjia Liu,Aroona Razzaq,Xuan Chen,Yujie Liao,Siyi Tao,Yuxing Liu,Lu Xu,Qianjun Zhang,Jian Peng,Xu Deng,Shanni Li,Taijiao Jiang,Zanxian Xia +22 more
TL;DR: In this article , a host E3 ligase, HUWE1, was identified that specifically induces MERS-CoV ORF3 protein ubiquitination and degradation through the ubiquitin-proteasome system.