P
Pinghui Feng
Researcher at University of Southern California
Publications - 87
Citations - 4509
Pinghui Feng is an academic researcher from University of Southern California. The author has contributed to research in topics: Lytic cycle & Innate immune system. The author has an hindex of 28, co-authored 76 publications receiving 3802 citations. Previous affiliations of Pinghui Feng include Harvard University & Pusan National University.
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Journal ArticleDOI
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
TL;DR: UVRAG is identified as an essential component of the Beclin1–PI(3)KC3 lipid kinase complex that is an important signalling checkpoint for autophagy and tumour-cell growth.
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Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
Chengyu Liang,Chengyu Liang,Jong-Soo Lee,Jong-Soo Lee,Kyung-Soo Inn,Kyung-Soo Inn,Michaela U. Gack,Michaela U. Gack,Qinglin Li,Esteban A. Roberts,Isabelle Vergne,Vojo Deretic,Pinghui Feng,Chihiro Akazawa,Jae U. Jung,Jae U. Jung +15 more
TL;DR: It is reported that a Beclin1-binding autophagic tumour suppressor, UVRAG, interacts with the class C Vps complex, a key component of the endosomal fusion machinery, and this interaction stimulates Rab7 GTPase activity and autophagosome fusion with late endosomes/lysosomes, thereby enhancing delivery and degradation of Autophagic cargo.
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mRNA degradation by the virion host shutoff (VHS) protein of herpes simplex virus: Genetic and biochemical evidence that VHS is a nuclease
TL;DR: Genetic and biochemical evidence is provided that Vhs is an RNase, either alone or as a complex with eIF4H.
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Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway.
Gil Ju Seo,Aerin Yang,Brandon Tan,Sungyoon Kim,Qiming Liang,Younho Choi,Weiming Yuan,Pinghui Feng,Hee-Sung Park,Jae U. Jung +9 more
TL;DR: It is shown that Akt kinase plays a negative role in cGAS-mediated anti-viral immune response and an AkT kinase-mediated checkpoint is identified to fine-tune hosts' immune responses to DNA stimulation.
Journal ArticleDOI
Inhibition of the ATM/p53 Signal Transduction Pathway by Kaposi's Sarcoma-Associated Herpesvirus Interferon Regulatory Factor 1
Young C. Shin,Hiroyuki Nakamura,Xiaozhen Liang,Pinghui Feng,Heesoon Chang,Timothy F. Kowalik,Jae U. Jung +6 more
TL;DR: KSHV vIRF1 comprehensively compromises an ATM/p53-mediated DNA damage response checkpoint by targeting both upstream ATM kinase and downstream p53 tumor suppressor, which might circumvent host growth surveillance and facilitate viral replication in infected cells.