S
Silvia Castelletti
Researcher at University College London
Publications - 99
Citations - 2353
Silvia Castelletti is an academic researcher from University College London. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 21, co-authored 71 publications receiving 1510 citations. Previous affiliations of Silvia Castelletti include St Bartholomew's Hospital & University of Pavia.
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Journal ArticleDOI
Native T1 mapping in transthyretin amyloidosis
Marianna Fontana,Sanjay M Banypersad,Thomas A. Treibel,Viviana Maestrini,Daniel Sado,Steven K White,Silvia Pica,Silvia Castelletti,Stefan K. Piechnik,Matthew D. Robson,Janet A. Gilbertson,Dorota Rowczenio,David F. Hutt,Helen J. Lachmann,Ashutosh D. Wechalekar,Carol J. Whelan,Julian D. Gillmore,Philip N. Hawkins,James C. Moon +18 more
TL;DR: Native myocardial T1 mapping detects cardiac ATTR amyloid with similar diagnostic performance and disease tracking to AL amyloids, but with lower maximal T1 elevation, and appears to be an early disease marker.
Journal ArticleDOI
Occult Transthyretin Cardiac Amyloid in Severe Calcific Aortic Stenosis Prevalence and Prognosis in Patients Undergoing Surgical Aortic Valve Replacement
Thomas A. Treibel,Marianna Fontana,Janet A. Gilbertson,Silvia Castelletti,Steven K White,Paul Scully,Neil Roberts,David F. Hutt,Dorota Rowczenio,Carol J. Whelan,M Ashworth,Julian D. Gillmore,Philip N. Hawkins,James C. Moon +13 more
TL;DR: In this paper, the authors explored the prevalence of wild-type transthyretin amyloid in cAS by myocardial biopsy, its imaging phenotype and prognostic significance.
Journal ArticleDOI
Spectrum and prevalence of mutations involving BrS1- through BrS12-susceptibility genes in a cohort of unrelated patients referred for Brugada syndrome genetic testing: implications for genetic testing
Lia Crotti,Cherisse A. Marcou,David J. Tester,Silvia Castelletti,John R. Giudicessi,Margherita Torchio,Argelia Medeiros-Domingo,Savastano Simone,Melissa L. Will,Federica Dagradi,Peter J. Schwartz,Michael J. Ackerman +11 more
TL;DR: The spectrum and prevalence of mutations in the 12 Brugada syndrome (BrS)-susceptibility genes discovered to date in a single large cohort of unrelated BrS patients were provided to date and putative pathogenic mutations were identified.
Journal ArticleDOI
Automatic Measurement of the Myocardial Interstitium: Synthetic Extracellular Volume Quantification Without Hematocrit Sampling.
Thomas A. Treibel,Marianna Fontana,Viviana Maestrini,Silvia Castelletti,Stefania Rosmini,Joanne Simpson,Arthur Nasis,Anish N Bhuva,Heerajnarain Bulluck,Amna Abdel-Gadir,Steven K White,Charlotte Manisty,Bruce S Spottiswoode,Timothy C. Wong,Stefan K. Piechnik,Peter Kellman,Matthew D. Robson,Erik B. Schelbert,James C. Moon +18 more
TL;DR: Synthetic ECV provides validated noninvasive quantification of the myocardial extracellular space without blood sampling and is associated with cardiovascular outcomes.
Journal ArticleDOI
Reference values of cardiac volumes, dimensions, and new functional parameters by MR: A multicenter, multivendor study
Giovanni Donato Aquaro,Giovanni Camastra,Lorenzo Monti,Massimo Lombardi,Alessia Pepe,Silvia Castelletti,Viviana Maestrini,Giancarlo Todiere,Pier Giorgio Masci,Gabriella Di Giovine,Andrea Barison,Santo Dellegrottaglie,Martina Perazzolo Marra,Gianluca Pontone,Gianluca Di Bella +14 more
TL;DR: In this paper, the authors defined reference values of cardiac volumes, dimensions, and new morpho-functional parameters normalized for age, gender, and body surface area by cine-bSSFP (balanced steady-state free-precession) magnetic resonance (MR).