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Silvia Castelletti
Researcher at University College London
Publications - 99
Citations - 2353
Silvia Castelletti is an academic researcher from University College London. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 21, co-authored 71 publications receiving 1510 citations. Previous affiliations of Silvia Castelletti include St Bartholomew's Hospital & University of Pavia.
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Journal ArticleDOI
A wearable remote monitoring system for the identification of subjects with a prolonged QT interval or at risk for drug-induced long QT syndrome.
Silvia Castelletti,Federica Dagradi,Karine Goulene,Aurora Ilaria Danza,Enrico Baldi,Marco Stramba-Badiale,Peter J. Schwartz +6 more
TL;DR: This wearable monitoring system reliably identifies a prolonged QT interval and probably also subjects at risk for diLQTS.
Journal ArticleDOI
SCN5A Mutation Type and a Genetic Risk Score Associate Variably With Brugada Syndrome Phenotype in SCN5A Families
Yanushi D. Wijeyeratne,Michael W.T. Tanck,Yuka Mizusawa,Velislav N. Batchvarov,Julien Barc,Lia Crotti,J. Martijn Bos,David J. Tester,Alison Muir,Christian Veltmann,Seiko Ohno,Stephen P. Page,Joseph Galvin,Rafik Tadros,Martina Muggenthaler,Hariharan Raju,Isabelle Denjoy,Jean-Jacques Schott,Jean-Baptiste Gourraud,Doris Škorić-Milosavljević,Eline A. Nannenberg,Richard Redon,Michael Papadakis,F. Kyndt,Federica Dagradi,Silvia Castelletti,Margherita Torchio,Thomas Meitinger,Peter Lichtner,Taisuke Ishikawa,Arthur A.M. Wilde,Kazuhiro Takahashi,Sanjay Sharma,Dan M. Roden,Martin Borggrefe,Pascal P. McKeown,Pascal P. McKeown,Wataru Shimizu,Minoru Horie,Naomasa Makita,Takeshi Aiba,Michael J. Ackerman,Peter J. Schwartz,Vincent Probst,Connie R. Bezzina,Elijah R. Behr +45 more
TL;DR: Common genetic variation is associated with variable expressivity of BrS phenotype in SCN5A families, explaining in part incomplete penetrance and genotype-negative phenotype-positive individuals.
Journal ArticleDOI
Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Julien Barc,Rafik Tadros,Charlotte Glinge,David Y. Chiang,Mariam Jouni,Floriane Simonet,Sean J. Jurgens,M Baudic,Michele Nicastro,Franck Potet,Joost A. Offerhaus,Roddy Walsh,Seung Hoan Choi,Arie O. Verkerk,Yuka Mizusawa,S Anys,Damien Minois,Marine Arnaud,Josselin Duchateau,Yanushi D. Wijeyeratne,Alison Muir,Michael Papadakis,Silvia Castelletti,Margherita Torchio,Cristina Gil Ortuño,Javier Lacunza,Daniela Giachino,Natascia Cerrato,Raphaël P. Martins,Oscar Campuzano,Sonia Van Dooren,Aurélie Thollet,Florence Kyndt,Andrea Mazzanti,Nicolas Clementy,Arnaud Bisson,Anniek Corveleyn,Birgit Stallmeyer,Sven Dittmann,Johan Saenen,Antoine Noël,Shohreh Honarbakhsh,Boris Rudic,Halim Marzak,Matthew K. Rowe,Claire Federspiel,Sophie L. Le Page,Leslie Placide,A. Milhem,Hector Barajas-Martinez,Britt M. Beckmann,Ingrid P.C. Krapels,Johannes Steinfurt,Bo Gregers Winkel,Reza Jabbari,M. Benjamin Shoemaker,Bastiaan J. Boukens,Doris Škorić-Milosavljević,Hennie Bikker,Federico Manevy,Peter Lichter,Marta Ribasés,Thomas Meitinger,Martina Müller-Nurasyid,Konstantin Annette Holger Lars Reiner Margit Strauch Peters Schulz Schwettmann Leidl Heier,Konstantin Strauch,Annette Peters,Holger Schulz,Lars Schwettmann,Reiner Leidl,Margit Heier,Jan H. Veldink,Leonard H. van den Berg,Philip Van Damme,Daniele Cusi,Chiara Lanzani,Sidwell Rigade,Eric Charpentier,Estelle Baron,Stéphanie Bonnaud,Simon Lecointe,Audrey Donnart,Hervé Le Marec,Stéphanie Chatel,Matilde Karakachoff,Stéphane Bézieau,Barry London,Jacob Tfelt-Hansen,Dan M. Roden,Katja E. Odening,Marina Cerrone,Larry A. Chinitz,Paul G.A. Volders,Maarten P. van de Berg,Guy Laurent,Laurence Faivre,Charles Antzelevitch,Stefan Kääb,A. Al Arnaout,Jean-Marc Dupuis,Jean-Luc Pasquié,Olivier Billon,Jason D. Roberts,Laurence Jesel,Martin Borggrefe,Pier D. Lambiase,Jacques Mansourati,Bart Loeys,Antoine Leenhardt,Pascale Guicheney,Philippe Maury,Eric Schulze-Bahr,Tomas Robyns,Jeroen Breckpot,Dominique Babuty,Silvia G. Priori,Carlo Napolitano,Pascal Frédéric Jean Philippe François Defaye Anselme Darmon Wiart,Pascal Defaye,Frédéric Anselme,Jean-Philippe Darmon,F Wiart,Carlo de Asmundis,Pedro Brugada,Ramon Brugada,Elena Arbelo,Josep Brugada,Philippe Mabo,Nathalie Behar,Carla Giustetto,Maria Sabater Molina,Juan R. Gimeno,Can Hasdemir,Peter J. Schwartz,Lia Crotti,Pascal P. McKeown,Sanjay Sharma,Elijah R. Behr,Michel Haïssaguerre,Frederic Sacher,Caroline Rooryck,Hanno L. Tan,Carol Ann Remme,Pieter G. Postema,Mario Delmar,Patrick T. Ellinor,Steven A. Lubitz,Jean-Baptiste Gourraud,Michael W.T. Tanck,Alfred L. George,Calum A. MacRae,Paul W. Burridge,Christian Dina,Vincent Probst,Arthur A.M. Wilde,Jean-Jacques Schott,Richard Redon,Connie R. Bezzina +157 more
TL;DR: In this paper , a genome-wide association meta-analysis was performed to identify new susceptibility genes for Brugada syndrome, including new susceptibility loci for SCN5A and MAPRE2, encoding the microtubule plus-end binding protein EB2.
Journal ArticleDOI
The genetics underlying idiopathic ventricular fibrillation: A special role for catecholaminergic polymorphic ventricular tachycardia?
Jaakko T. Leinonen,Lia Crotti,Aurora Djupsjöbacka,Silvia Castelletti,Nella Junna,Alice Ghidoni,Annukka M. Tuiskula,Carla Spazzolini,Federica Dagradi,Matti Viitasalo,Kimmo Kontula,Maria Christina Kotta,Elisabeth Widen,Heikki Swan,Peter J. Schwartz +14 more
TL;DR: The results of this study suggest that a subset of patients originally diagnosed with IVF may carry clinically-relevant variants in genes associated with cardiac channelopathies and cardiomyopathies, potentially contributing to the life-threatening arrhythmias of these patients.
Journal ArticleDOI
Loss-of-function desmoplakin I and II mutations underlie dominant arrhythmogenic cardiomyopathy with a hair and skin phenotype.
T. Maruthappu,A. Posafalvi,Silvia Castelletti,Paul J. Delaney,Petros Syrris,Edel A. O'Toole,Kathleen J. Green,Perry M. Elliott,Pier D. Lambiase,Pier D. Lambiase,Andrew Tinker,William J. McKenna,David P. Kelsell +12 more
TL;DR: Arrhythmogenic cardiomyopathy is an inherited, frequently underdiagnosed disorder, which can predispose individuals to sudden cardiac death.