Silvia D. Stan

TL;DR: The WA treatment decreased viability of MCF-7 and MDA-MB-231 human breast cancer cells in a concentration-dependent manner and pointed toward an important role of FOXO3a and Bim in regulation of WA-mediated apoptosis in human breast cancers.

TL;DR: The results of the present study indicate that SFN administration inhibits prostate cancer progression and pulmonary metastasis in TRAMP mice by reducing cell proliferation and augmenting NK cell lytic activity.

TL;DR: Current knowledge on cancer chemopreventive effects of a few highly promising dietary constituents, including garlic‐derived organosulfides, berry compounds, and cruciferous vegetable‐derived isothiocyanates is reviewed, and serves to illustrate complexity of the signal transduction mechanisms in cancerChemoprevention by these promising bioactive food components.

TL;DR: The results of this study suggest that G2-M phase cell cycle arrest may be an important mechanism in antiproliferative effect of WA against human breast cancer cells.

TL;DR: The current state of the pancreatic cancer chemopreventive field is discussed, the challenges ahead are highlighted and further development of pancreatic Cancer Chemoprevention agents may prove to be tremendously valuable for individuals at high risk of developing Pancreatic cancer and patients who present with premalignant lesions.