D
Dhimant Desai
Researcher at Pennsylvania State University
Publications - 186
Citations - 5595
Dhimant Desai is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Cancer & Carcinogen. The author has an hindex of 39, co-authored 166 publications receiving 4938 citations. Previous affiliations of Dhimant Desai include Penn State Cancer Institute & Penn State Milton S. Hershey Medical Center.
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Journal ArticleDOI
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang,Changtao Jiang,Cen Xie,Fei Li,Limin Zhang,Robert G. Nichols,Kristopher W. Krausz,Jingwei Cai,Yunpeng Qi,Zhong-Ze Fang,Shogo Takahashi,Naoki Tanaka,Dhimant Desai,Shantu Amin,Istvan Albert,Andrew D. Patterson,Frank J. Gonzalez +16 more
TL;DR: It is demonstrated that inhibition of an intestinal FXR/ceramide axis mediates gut microbiota-associated NAFLD development, linking the microbiome, nuclear receptor signaling, andNAFLD.
Journal ArticleDOI
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction.
Changtao Jiang,Cen Xie,Ying Lv,Jing Li,Kristopher W. Krausz,Jingmin Shi,Chad Brocker,Dhimant Desai,Shantu Amin,William H. Bisson,Yulan Liu,Oksana Gavrilova,Andrew D. Patterson,Frank J. Gonzalez +13 more
TL;DR: Treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity, suggesting that Gly-M CA may be a candidate for the treatment of metabolic disorders.
Journal ArticleDOI
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.
Shivendra V. Singh,Renaud Warin,Dong Xiao,Anna A. Powolny,Silvia D. Stan,Julie A. Arlotti,Yan Zeng,Eun-Ryeong Hahm,Stanley W. Marynowski,Ajay Bommareddy,Dhimant Desai,Shantu Amin,Robert A. Parise,Jan H. Beumer,William H. Chambers +14 more
TL;DR: The results of the present study indicate that SFN administration inhibits prostate cancer progression and pulmonary metastasis in TRAMP mice by reducing cell proliferation and augmenting NK cell lytic activity.
Journal ArticleDOI
CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice
Carol S. Trempus,Rebecca J. Morris,Matthew Ehinger,Amy Elmore,Carl D. Bortner,Mayumi Ito,George Cotsarelis,Joanne G.W. Nijhof,John C. Peckham,Norris D. Flagler,Grace E. Kissling,Margaret M. Humble,Leon C. King,Linda D. Adams,Dhimant Desai,Shantu Amin,Raymond W. Tennant +16 more
TL;DR: Data show that CD34 is required for TPA-induced hair follicle stem cell activation and tumor formation in mice.
Journal ArticleDOI
Effect of caffeic acid esters on carcinogen-induced mutagenicity and human colon adenocarcinoma cell growth.
TL;DR: Caffeic acid esters which are present in Propolis possess chemopreventive properties when tested in short-term assay systems, and indicate that MC, PEC and PEDMC were not mutagenic in the Salmonella tester system.