S
Silvia Hernández-Ainsa
Researcher at University of Zaragoza
Publications - 44
Citations - 1425
Silvia Hernández-Ainsa is an academic researcher from University of Zaragoza. The author has contributed to research in topics: Dendrimer & DNA origami. The author has an hindex of 19, co-authored 40 publications receiving 1169 citations. Previous affiliations of Silvia Hernández-Ainsa include Spanish National Research Council & University of Cambridge.
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Journal ArticleDOI
Single protein molecule detection by glass nanopores.
Wenhong Li,Nicholas A. W. Bell,Silvia Hernández-Ainsa,Vivek V. Thacker,Alana M. Thackray,Raymond Bujdoso,Ulrich F. Keyser +6 more
TL;DR: This work shows for the first time solid state nanopore measurements of mammalian prion protein, which in its abnormal form is associated with transmissible spongiform encephalopathies, and provides a basis for protein characterization and the study of protein conformational diseases by nanopore detection.
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DNA-Tile Structures Induce Ionic Currents through Lipid Membranes
Kerstin Göpfrich,Thomas Zettl,Thomas Zettl,Anna E. C. Meijering,Silvia Hernández-Ainsa,Samet Kocabey,Tim Liedl,Ulrich F. Keyser +7 more
TL;DR: By demonstrating the design of DNA-based membrane channels with openings much smaller than that of the archetypical six-helix bundle, this work showcases their versatility inspired by the rich diversity of natural membrane components.
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DNA origami nanopores for controlling DNA translocation.
Silvia Hernández-Ainsa,Nicholas A. W. Bell,Vivek V. Thacker,Kerstin Göpfrich,Karolis Misiunas,Maria Eugenia Fuentes-Perez,Fernando Moreno-Herrero,Ulrich F. Keyser +7 more
TL;DR: It is shown that the specific introduction of binding sites in the DNA origami nanopore allows selective detection of ssDNA as a function of the DNA sequence ("chemical control").
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Ionic conductivity, structural deformation, and programmable anisotropy of DNA origami in electric field.
Chen-Yu Li,Elisa A. Hemmig,Jinglin Kong,Jejoong Yoo,Silvia Hernández-Ainsa,Ulrich F. Keyser,Aleksei Aksimentiev +6 more
TL;DR: A comprehensive characterization of the ionic conductivity of DNA origami plates by means of all-atom molecular dynamics simulations and nanocapillary electric current recordings and demonstrates feasibility of programming the electrical properties of a self-assembled nanoscale object using DNA.
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DNA origami nanopores: developments, challenges and perspectives.
TL;DR: The current challenges and possible solutions that would enhance the sensing capabilities of DNA origami nanopores are discussed and a range of exciting ideas and applications that could be explored in the near future are highlighted.