Silvia Matteoni

TL;DR: When autophagy is induced, ULK1 phosphorylates AMBRA1, releasing the autophagic core complex from the cytoskeleton and allowing its relocalization to the ER membrane to nucleate autophagosome formation.

TL;DR: The authors identify the RNA interacting factors NONO and SFPQ as proteins that interact with TERRA and telomere chromatin and reveal putative roles for these factors in telomeres integry maintenance by interfering with RNA:DNA hybrid formation.

TL;DR: The role of PTEN expression and function and downstream pathway activation in cancer stem cell biology and regulation of the tumorigenic potential is focused on; the emerging role ofPTEN in mediating the crosstalk between the PI3K and MAPK pathways will also be discussed.

TL;DR: The spiraling costs of new antineoplastic drugs and the long time required for them to reach the market demands a profoundly different approach to keep lifesaving therapies affordable for cancer patients and repurposing can represent a relatively inexpensive, safe and fast approach to glioblastoma treatment.

TL;DR: The development of a suitable procedure for protein extraction from the cow MFGs is developed in order to qualitatively and quantitatively improve 2-D electropherograms of the MFG.