C
Claudia Fuoco
Researcher at University of Rome Tor Vergata
Publications - 65
Citations - 3074
Claudia Fuoco is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topics: Skeletal muscle & Adipogenesis. The author has an hindex of 18, co-authored 52 publications receiving 2406 citations.
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Journal ArticleDOI
Ambra1 regulates autophagy and development of the nervous system
Gian Maria Fimia,Anastassia Stoykova,Alessandra Romagnoli,Luigi Giunta,Sabrina Di Bartolomeo,Roberta Nardacci,Marco Corazzari,Claudia Fuoco,Ahmet Ucar,Peter Schwartz,Peter Gruss,Mauro Piacentini,Kamal Chowdhury,Francesco Cecconi +13 more
TL;DR: It is shown that Ambra1 (activating molecule in Beclin1-regulated autophagy), a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulatesAutophagy and has a crucial role in embryogenesis, and provides in vivo evidence supporting the existence of a complex interplay between autphagy, cell growth and cell death required for neural development in mammals.
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The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
Sabrina Di Bartolomeo,Marco Corazzari,Francesca Nazio,Serafina Oliverio,Gaia Lisi,Manuela Antonioli,Vittoria Pagliarini,Silvia Matteoni,Claudia Fuoco,Luigi Giunta,Marcello D'Amelio,Roberta Nardacci,Alessandra Romagnoli,Mauro Piacentini,Francesco Cecconi,Gian Maria Fimia +15 more
TL;DR: When autophagy is induced, ULK1 phosphorylates AMBRA1, releasing the autophagic core complex from the cytoskeleton and allowing its relocalization to the ER membrane to nucleate autophagosome formation.
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Oxidative stress preconditioning of mouse perivascular myogenic progenitors selects a subpopulation of cells with a distinct survival advantage in vitro and in vivo.
Cesare Gargioli,Giuseppina Turturici,Maria Magdalena Barreca,Walter Spinello,Claudia Fuoco,Stefano Testa,Salvatore Feo,Stefano Cannata,Giulio Cossu,Gabriella Sconzo,Fabiana Geraci +10 more
TL;DR: The positive effects of sorting on mesoangioblast cell behaviour in vitro and in vivo suggest that a selection step involving oxidative stress preconditioning may provide a novel methodology to select for resistant cells for use in regenerative tissue applications to prevent high mortality rates upon transplantation.
Journal ArticleDOI
Microfluidic-enhanced 3D bioprinting of aligned myoblast-laden hydrogels leads to functionally organized myofibers in vitro and in vivo
Marco Costantini,Stefano Testa,Pamela Mozetic,Andrea Barbetta,Claudia Fuoco,Ersilia Fornetti,Francesco Tamiro,Sergio Bernardini,Jakub Jaroszewicz,Wojciech Święszkowski,Marcella Trombetta,Luisa Castagnoli,Dror Seliktar,Piotr Garstecki,Gianni Cesareni,Stefano Cannata,Alberto Rainer,Cesare Gargioli +17 more
TL;DR: The results demonstrate an enhanced myogenic differentiation with the formation of parallel aligned long-range myotubes within the 3D bioprinted fibers, further revealing maturation, sarcomerogenesis, and functionality.
Journal ArticleDOI
Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells
Marco Orecchioni,Davide Bedognetti,Leon Newman,Claudia Fuoco,Filomena Spada,Wouter Hendrickx,Francesco M. Marincola,Francesco Sgarrella,Artur Filipe Rodrigues,Cécilia Ménard-Moyon,Gianni Cesareni,Kostas Kostarelos,Alberto Bianco,Lucia Gemma Delogu,Lucia Gemma Delogu +14 more
TL;DR: The interaction of graphene oxide nanomaterials and several immune cell subpopulations are investigated using single-cell mass cytometry and genome-wide transcriptome analysis and shows that the amine groups reduce the perturbations caused by GO on cell metabolism and increase biocompatibility.