S
Silvio Varon
Researcher at University of California, San Diego
Publications - 9
Citations - 1172
Silvio Varon is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Axon & Nerve guidance conduit. The author has an hindex of 8, co-authored 9 publications receiving 1146 citations.
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Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TL;DR: Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.
Journal ArticleDOI
Nerve regeneration across an extended gap: A neurobiological view of nerve repair and the possible involvement of neuronotrophic factors
Göran Lundborg,Lars-Bertil Dahlin,Nils Danielsen,Hans-Arne Hansson,Ann Johannesson,Frank M. Longo,Silvio Varon +6 more
TL;DR: The results suggest that if the regrowing proximal stump is in an appropriate environment, it can form a well organized and oriented nerve trunk, which may also support nerve regeneration in vivo.
Journal ArticleDOI
Exogenous matrix precursors promote functional nerve regeneration across a 15‐mm gap within a silicone chamber in the rat
TL;DR: Modification of matrix formation was found to promote successful regeneration across 15‐mm and 20‐mm interstump gap lengths and resulted in a 3.5‐fold increase in the incidence of functional restitution detected at 8 weeks after implantation over the outcome with chambers prefilled with phosphate‐buffered saline.
Journal ArticleDOI
Fibroblast growth factor effects on peripheral nerve regeneration in a silicone chamber model.
TL;DR: It is concluded that FGF stimulates peripheral nerve regeneration in this model because of the well‐developed vascular arborization of the regenerate within the FGF chambers.
Journal ArticleDOI
Characterization of neurotrophic activity in the silicone-chamber model for nerve regeneration.
Nils Danielsen,Silvio Varon +1 more
TL;DR: There was one major peak of neurotrophic activity and this activity peaked early, about 3 to 6 hr after nerve injury, and results indicate that the chamber fluid contains at least two types of neurotroph activities, namely nerve growth factor and ciliary neurotrophic factor.