Journal ArticleDOI
Nerve regeneration in silicone chambers : influence of gap length and of distal stump components
Göran Lundborg,Lars B. Dahlin,Nils Danielsen,Richard H. Gelberman,Frank M. Longo,Henry C. Powell,Silvio Varon +6 more
TLDR
Observations confirm that the distal stump influences proximal regeneration and indicate that this influence can act only over a limited distance or volume.About:
This article is published in Experimental Neurology.The article was published on 1982-05-01. It has received 607 citations till now.read more
Citations
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Journal ArticleDOI
The cellular and molecular basis of peripheral nerve regeneration.
Susan Y. Fu,Tessa Gordon +1 more
TL;DR: Axonal regeneration may be facilitated by new strategies that enhance the growth potential of neurons and optimize the growth support of the distal nerve stump in combination with prompt nerve repair.
PatentDOI
Peripheral nerve regeneration
James W. Fawcett,Roger J. Keynes +1 more
TL;DR: Basal lamina grafts for reconnecting severed nerves are prepared from muscle by removing cellular material therefrom while preserving the tubular structure of the basal lamina, eventually reestablishing nerve function through the regenerated graft.
Journal ArticleDOI
A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance.
TL;DR: In spite of an enormous amount of new experimental laboratory data based on evolving neuroscientific concepts during the last 25 years, peripheral nerve injuries still belong to the most challenging and difficult surgical reconstructive problems.
Journal ArticleDOI
Schwann cells, neurotrophic factors, and peripheral nerve regeneration
TL;DR: This review article focuses on the roles in peripheral nerve regeneration of Schwann cells and of the neurotrophin family, CNTF and GDNF, and the relationship between these and what remains to be understood about the possible clinical use of neurotrophic factors.
Journal ArticleDOI
Spatial‐Temporal progress of peripheral nerve regeneration within a silicone chamber: Parameters for a bioassay
TL;DR: The spatial‐temporal progress of peripheral nerve regeneration across a 10‐mmgap within a silicone chamber was examined and the parameters of a morphologic assay for regeneration in this chamber model can be used to investigate cellular and molecular mechanisms underlying the success of peripheral nerves regeneration.
References
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Journal ArticleDOI
Cell death in the development of the lateral motor column of the chick embryo.
TL;DR: Arguments are presented in support of the hypothesis that the naturally occurring cell death in the l.m.c. is due to the failure of their axons to survive in a competion process at the periphery, and observations of the time pattern of muscle differentiation and their neurotization in the leg further endorse this hypothesis.
Journal ArticleDOI
Nerve regeneration model and trophic factors in vivo
TL;DR: The proximal stump of a transected rat sciatic nerve has been observed to regenerate through a cylindrical silicone chamber across a 10 mm gap to the distal stump, indicating trophic factors that ensure in vitro survival and growth of at least sensory neurons from rodent dorsal root ganglia.
Journal ArticleDOI
In vivo regeneration of cut nerves encased in silicone tubes: growth across a six-millimeter gap.
TL;DR: An experimental in vivo system for studying peripheral nerve regeneration, in which the proximal stump of a transected nerve regrows through a transparent silicone chamber toward the distal stump, which permits easy collection of the extracellular fluid for analysis of its chemical properties and biological activity.
Book ChapterDOI
Trophic and Specifying Factors Directed to Neuronal Cells
Silvio Varon,Ruben Adler +1 more
TL;DR: This chapter examines the effects of trophic and specifying factors directed to neuronal cells, which provide qualitative instructions to the cells and define which particular cell behaviors are to benefit from the same Trophic drive.
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Clinical nerve reconstruction with a bioabsorbable polyglycolic acid tube
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