S
Simant Dube
Researcher at Fluidigm Corporation
Publications - 49
Citations - 3708
Simant Dube is an academic researcher from Fluidigm Corporation. The author has contributed to research in topics: Image processing & Image compression. The author has an hindex of 21, co-authored 48 publications receiving 3294 citations. Previous affiliations of Simant Dube include University of South Carolina & Microsoft.
Papers
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Journal ArticleDOI
High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number
Benjamin J. Hindson,Kevin D. Ness,Donald A. Masquelier,Phillip Belgrader,Nicholas J. Heredia,Anthony J. Makarewicz,Isaac J. Bright,Michael Y. Lucero,Amy L. Hiddessen,Tina C. Legler,Tyler K. Kitano,Michael R. Hodel,Jonathan Petersen,Paul Wyatt,Erin R. Steenblock,Pallavi Shah,Luc J. Bousse,Camille B. Troup,Jeffrey Clark Mellen,Dean K. Wittmann,Nicholas G. Erndt,Thomas H. Cauley,Ryan T. Koehler,Austin P. So,Simant Dube,Klint Rose,Luz Montesclaros,Shenglong Wang,David P. Stumbo,Shawn Hodges,Steven Romine,Fred P. Milanovich,Helen E. White,John F. Regan,George Karlin-Neumann,Christopher Hindson,Serge Saxonov,Bill W. Colston +37 more
TL;DR: A high-throughput droplet digital PCR system that enables processing of ∼2 million PCR reactions using conventional TaqMan assays with a 96-well plate workflow is described that will allow researchers to explore complex genetic landscapes, discover and validate new disease associations, and define a new era of molecular diagnostics.
Journal ArticleDOI
Mathematical Analysis of Copy Number Variation in a DNA Sample Using Digital PCR on a Nanofluidic Device
TL;DR: An algorithm is presented which is mathematically sound and computationally efficient to accurately analyze CNV in a DNA sample utilizing a nanofluidic device, known as the digital array, based on results from probability theory and statistics.
Journal ArticleDOI
Taking qPCR to a higher level: Analysis of CNV reveals the power of high throughput qPCR to enhance quantitative resolution.
Suzanne Weaver,Simant Dube,Alain Mir,Jian Qin,Gang Sun,Ramesh Ramakrishnan,Robert C. Jones,Kenneth J. Livak +7 more
TL;DR: This paper assesses the quantitative resolution of qPCR using copy number variation (CNV) as a paradigm, and an error model is developed for real-timeqPCR data showing how the precision of CNV determination varies with the number of replicates.
Patent
Method and apparatus for determining copy number variation using digital pcr
TL;DR: In this paper, a method of estimating a concentration of DNA molecules in a biological sample is proposed, which includes storing a number of a plurality of reaction sites in a memory and distributing the biological sample among the plurality of react sites.
Patent
Object recognition of feature-sparse or texture-limited subject matter
Simant Dube,Edward Hsiao +1 more
TL;DR: In this article, a feature-sparse or texture-limited object can be recognized by complementing local features and/or texture features with color, region-based, shape based, three-dimensional (3D), global, and or composite features.