Camille B. Troup

TL;DR: A high-throughput droplet digital PCR system that enables processing of ∼2 million PCR reactions using conventional TaqMan assays with a 96-well plate workflow is described that will allow researchers to explore complex genetic landscapes, discover and validate new disease associations, and define a new era of molecular diagnostics.

TL;DR: Using droplet digital polymerase chain reaction, SETBP1 mutations were identified in 17/56 of patients who were treated in the Children's Oncology Group sponsored clinical trial, AAML0122, and five-year event-free survival in patients with SET BP1 mutations was 18% ± 9% compared with 51% ± 8% for those without mutations.

TL;DR: The SARS-CoV-2 Omicron variant of concern (VoC) and its sublineages contain 31-36 mutations in spike and escape neutralization by most therapeutic antibodies as mentioned in this paper .

TL;DR: Results on the use of ddPCR for the detection and quantitation of several clinically important mutations, including KRAS, c-KIT D816V and JAK2 from clinical samples such as bone marrow aspirates and FFPE are presented.

TL;DR: It is concluded that the presence of a subclonal mutation in SETBP1 is a novel biomarker of adverse outcome in JMML, and the hypothesis that rare SETBP 1 mutant clones exist at diagnosis in many patients who relapse, and that these rare cells undergo positive selection during treatment is tested.