S
Simo Syrjälä
Researcher at University of Helsinki
Publications - 38
Citations - 342
Simo Syrjälä is an academic researcher from University of Helsinki. The author has contributed to research in topics: Heart transplantation & Transplantation. The author has an hindex of 9, co-authored 26 publications receiving 264 citations. Previous affiliations of Simo Syrjälä include Helsinki University Central Hospital.
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Journal ArticleDOI
Donor Simvastatin Treatment Abolishes Rat Cardiac Allograft Ischemia/Reperfusion Injury and Chronic Rejection Through Microvascular Protection
Raimo Tuuminen,Simo Syrjälä,Rainer Krebs,Mikko A. I. Keränen,Katri Koli,Usama Abo-Ramadan,Pertti J. Neuvonen,Jussi Tikkanen,Antti I. Nykänen,Karl B. Lemström +9 more
TL;DR: It is demonstrated that donor simvastatin treatment prevents microvascular endothelial cell and pericyte dysfunction, ischemia/reperfusion injury, and chronic rejection and suggest a novel, clinically feasible strategy to protect cardiac allografts.
Journal ArticleDOI
Angiopoietin-2 Inhibition Prevents Transplant Ischemia-Reperfusion Injury and Chronic Rejection in Rat Cardiac Allografts
Simo Syrjälä,R. Tuuminen,Antti I. Nykänen,Alireza Raissadati,A. Dashkevich,M. A. I. Keranen,M. A. I. Keranen,Ralica Arnaudova,Rainer Krebs,Ching Ching Leow,Pipsa Saharinen,Kari Alitalo,Kari Alitalo,Karl B. Lemström +13 more
TL;DR: It is demonstrated that neutralization of Ang2 prevents EC activation, leukocyte infiltration, Tx‐IRI and the development of chronic rejection in rat cardiac allografts.
Journal ArticleDOI
Ischemia–Reperfusion Injury Enhances Lymphatic Endothelial VEGFR3 and Rejection in Cardiac Allografts
Alexey Dashkevich,Alexey Dashkevich,Alireza Raissadati,Simo Syrjälä,Georgia Zarkada,Mikko A. I. Keränen,Raimo Tuuminen,Rainer Krebs,Andrey Anisimov,Michael Jeltsch,Veli-Matti Leppänen,Kari Alitalo,Antti I. Nykänen,Antti I. Nykänen,Karl B. Lemström,Karl B. Lemström +15 more
TL;DR: The results suggest that tissue damage rapidly changes lymphatic vessel phenotype, which, in turn, may shape the interplay of innate and adaptive immunity.
Journal ArticleDOI
Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat
Simo Syrjälä,M.A.I. Keranen,R. Tuuminen,Antti I. Nykänen,Markku Tammi,Rainer Krebs,Karl B. Lemström +6 more
TL;DR: It is demonstrated that preservation injury induced a cascade leading to an innate immune response that modulated the adaptive immune response towards Th17 rather than Th1 T-cell response in rat cardiac allografts and ultimately enhanced cardiac fibrosis and arterial occlusion.
Journal ArticleDOI
Donor Simvastatin Treatment in Heart Transplantation
Antti I. Nykänen,E. Holmström,Raimo Tuuminen,Rainer Krebs,Kishor Dhaygude,Matti Kankainen,Janne J. Jokinen,Jyri Lommi,Ilkka Helanterä,Anne Räisänen-Sokolowski,Simo Syrjälä,Karl B. Lemström +11 more
TL;DR: In this article, ischemia-reperfusion injury may compromise the short-term and long-term prognosis after heart transplantation, and experimental studies show that simvastatin administered to the organ donor...