Pipsa Saharinen

TL;DR: The essential, nonredundant functions of Jaks in cytokine signaling have been established, and deficiency of Jak3 is the basis of human autosomal recessive severe combined immunodeficiency (SCID); accordingly, a selective Jak3 inhibitor has been developed, forming a new class of immunosuppressive drugs.

TL;DR: It is shown that Ang1 induces unique Tie2 complexes in mobile and confluent endothelial cells, and distinct signalling proteins were preferentially activated by Tie2 in the cell–matrix and cell–cell contacts, where Ang2 inhibited Ang1-induced Tie2 activation.

TL;DR: The members of the VEGF-VEGFR family as well as the angiopoietin growth factors and their Tie receptors are discussed as potential novel targets for antiangiogenic and antilymphangiogens therapies.

TL;DR: A review of published data on vascular protective effects of Ang1 highlights the therapeutic potential of this ligand, as well as possible limitations to its use, and considers the data on Ang1 receptors.

TL;DR: The lymphatic vascular system is important for immune surveillance, tissue fluid homeostasis and fat absorption, and is involved in many pathological processes, including tumor metastasis and lymphedema, and administration of lymphangiogenic growth factors or their antagonists provides the possibility of targeting lymphatic vessels in human disease.