S
Simon Bub
Researcher at University of Erlangen-Nuremberg
Publications - 3
Citations - 13
Simon Bub is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Metalloproteinase & Cleavage (embryo). The author has an hindex of 1, co-authored 3 publications receiving 2 citations. Previous affiliations of Simon Bub include University of Kiel.
Papers
More filters
Journal ArticleDOI
Cell Surface Processing of CD109 by Meprin β Leads to the Release of Soluble Fragments and Reduced Expression on Extracellular Vesicles
Wiebke Lückstädt,Simon Bub,Simon Bub,Tomas Koudelka,Egor Pavlenko,Florian Peters,Prasath Somasundaram,Christoph Becker-Pauly,Ralph Lucius,Friederike Zunke,Philipp Arnold +10 more
TL;DR: In this article, the authors identify the metalloproteinase meprin β to cleave CD109 at the cell surface and induce the release of cleavage fragments of different size.
Journal ArticleDOI
Structural and functional properties of meprin β metalloproteinase with regard to cell signaling
Wenjia Li,Wiebke Lückstädt,Birte Wöhner,Simon Bub,Antonia Schulz,Eileen Socher,Philipp Arnold +6 more
TL;DR: The metalloproteinase meprin β plays an important role during collagen I deposition in the skin, mucus detachment in the small intestine and also regulates the abundance of different cell surface proteins such as the interleukin-6 receptor (IL-6R), the triggering receptor expressed on myeloid cells 2 (TREM2), the cluster of differentiation 99 (CD99), the amyloid precursor protein (APP) and the Cluster of differentiation 109 (CD109) as discussed by the authors.
Posted ContentDOI
A blood marker for Parkinson’s Disease: Neuronal exosome-derived α-synuclein
Annika Kluge,Josina Bunk,Eva Schaeffer,Alice Drobny,Wei Xiang,Henrike Knacke,Simon Bub,Wiebke Lückstädt,Philipp Arnold,Ralph Lucius,Daniela Berg,Friederike Zunke +11 more
TL;DR: This study demonstrates that the detection of pathological α-synuclein conformers from neuron-derived exosomes from plasma samples has the potential of a promising blood-biomarker of PD.