F
Florian Peters
Researcher at University of Kiel
Publications - 16
Citations - 203
Florian Peters is an academic researcher from University of Kiel. The author has contributed to research in topics: Ectodomain & Medicine. The author has an hindex of 7, co-authored 13 publications receiving 120 citations. Previous affiliations of Florian Peters include University of Zurich.
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Journal ArticleDOI
Degradome of soluble ADAM10 and ADAM17 metalloproteases
Franka Scharfenberg,Andreas O. Helbig,Martin Sammel,Julia Benzel,Uwe Schlomann,Florian Peters,Rielana Wichert,Maximilian Bettendorff,Dirk Schmidt-Arras,Stefan Rose-John,Catherine Moali,Stefan F. Lichtenthaler,Stefan F. Lichtenthaler,Claus U. Pietrzik,Jörg W. Bartsch,Andreas Tholey,Christoph Becker-Pauly +16 more
TL;DR: The first degradome study for sADAM10/17 is presented, thereby introducing a new mode of proteolytic activity within the protease web.
Journal ArticleDOI
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin β and promotes transendothelial cell migration.
Tillmann Bedau,Florian Peters,Johannes Prox,Philipp Arnold,Frederike Schmidt,Malin Finkernagel,Sandra Köllmann,Rielana Wichert,Anna Otte,Anke Ohler,Marit Stirnberg,Ralph Lucius,Tomas Koudelka,Andreas Tholey,Valentina Biasin,Claus U. Pietrzik,Grazyna Kwapiszewska,Christoph Becker-Pauly +17 more
TL;DR: This study used biochemical and cellular assays to show that CD99 undergoes ectodomain shedding by the metalloprotease meprin β and subsequent intramembrane proteolysis by γ‐secretase, and suggests coevolution of protease and substrate.
Journal ArticleDOI
Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes
Florian Peters,Franka Scharfenberg,Cynthia Colmorgen,Fred Armbrust,Rielana Wichert,Philipp Arnold,Barbara Potempa,Jan Potempa,Claus U. Pietrzik,Robert Häsler,Philip Rosenstiel,Christoph Becker-Pauly +11 more
TL;DR: This study identified human meprin α and mePRin β as forming covalently linked membrane‐tethered heterodimers in the early endoplasmic reticulum, thereby preventing furin‐mediated secretion of meprins, and observed an increased proteolytic potential at the plasma membrane.
Journal ArticleDOI
Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.
Martin Sammel,Florian Peters,Juliane Lokau,Franka Scharfenberg,Ludwig Werny,Stefan Linder,Christoph Garbers,Stefan Rose-John,Christoph Becker-Pauly +8 more
TL;DR: It is shown that several metalloproteases, namely ADAM9, ADAM10, ADam17, meprin β, and membrane-type 1 matrix metallOProtease/matrix met alloprotease-14 (MT1-MMP/MMP-14) when overexpressed are able to shed the IL-11R.
Journal ArticleDOI
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Tillmann Bedau,Neele Schumacher,Florian Peters,Johannes Prox,Philipp Arnold,Tomas Koudelka,Ole Helm,Frederike Schmidt,Björn Rabe,Marlene Jentzsch,Philip Rosenstiel,Susanne Sebens,Andreas Tholey,Stefan Rose-John,Christoph Becker-Pauly +14 more
TL;DR: An acute inflammation model was employed and found significantly less infiltrated cells in meprin β knock-out animals validating the previously observed pro-inflammatory activity and identified mePRin β as a potent inducer of Src phosphorylation.