Simon J. L. Petitjean

TL;DR: It is demonstrated, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and the kinetic and thermodynamic properties of this binding pocket are extracted.

TL;DR: In this article , the role of sialic acids (SA) in early binding events of SARS-CoV-2 was studied using atomic force microscopy to study the early binding of the virus to the host cell.

TL;DR: Koehler et al. as discussed by the authors used single-virus force spectroscopy and confocal microscopy to discover a direct interaction between reovirus and β1 integrins.

TL;DR: This work used force-distance curve-based atomic force microscopy to quantify the binding between TIM-1/DC-SIGNR and EBOV glycoprotein (GP) and observed that both receptors specifically bind to GP with high-affinity.

TL;DR: In vitro data demonstrate the potential of S. miltiorrhiza against COVID-19, consisting first of the blockade of the binding of SARS-CoV-2 to the ACE2 receptor and the mitigation of the inflammatory response from leukocytes by interfering with NFκB signaling, and prompts the launch of a clinical trial to address in vivo the clinical benefits of this promising agent.