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Simon J. L. Petitjean
Researcher at Université catholique de Louvain
Publications - 9
Citations - 495
Simon J. L. Petitjean is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 2, co-authored 2 publications receiving 179 citations.
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Journal ArticleDOI
Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor.
Jinsung Yang,Simon J. L. Petitjean,Melanie Koehler,Qingrong Zhang,Andra C. Dumitru,Wenzhang Chen,Sylvie Derclaye,Stéphane P. Vincent,Patrice Soumillion,David Alsteens +9 more
TL;DR: It is demonstrated, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and the kinetic and thermodynamic properties of this binding pocket are extracted.
Journal ArticleDOI
Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
Simon J. L. Petitjean,Wen‐Zhang Chen,Melanie Koehler,Ravikumar Jimmidi,Jinsung Yang,Dana Mohammed,Blinera Juniku,Megan L. Stanifer,Steeve Boulant,Stéphane P. Vincent,David Alsteens +10 more
TL;DR: In this article , the role of sialic acids (SA) in early binding events of SARS-CoV-2 was studied using atomic force microscopy to study the early binding of the virus to the host cell.
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Reovirus directly engages integrin to recruit clathrin for entry into host cells.
Melanie Koehler,Simon J. L. Petitjean,Jinsung Yang,Pavithra Aravamudhan,Pavithra Aravamudhan,Xayathed Somoulay,Xayathed Somoulay,Cristina Lo Giudice,Mégane A. Poncin,Andra C. Dumitru,Terence S. Dermody,Terence S. Dermody,David Alsteens +12 more
TL;DR: Koehler et al. as discussed by the authors used single-virus force spectroscopy and confocal microscopy to discover a direct interaction between reovirus and β1 integrins.
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Stepwise Enzymatic-Dependent Mechanism of Ebola Virus Binding to Cell Surface Receptors Monitored by AFM.
Qingrong Zhang,Jinsung Yang,Sueli Tillieux,Zhengyuan Guo,Rita Dos Santos Natividade,Melanie Koehler,Simon J. L. Petitjean,Zongqiang Cui,David Alsteens +8 more
TL;DR: This work used force-distance curve-based atomic force microscopy to quantify the binding between TIM-1/DC-SIGNR and EBOV glycoprotein (GP) and observed that both receptors specifically bind to GP with high-affinity.
Journal ArticleDOI
Salvia miltiorrhiza Bunge as a Potential Natural Compound against COVID-19
Simon J. L. Petitjean,Marylène Lecocq,Camille Lelong,Robin Denis,Sylvie Defrère,Pierre-Antoine Mariage,David Alsteens,Charles Pilette +7 more
TL;DR: In vitro data demonstrate the potential of S. miltiorrhiza against COVID-19, consisting first of the blockade of the binding of SARS-CoV-2 to the ACE2 receptor and the mitigation of the inflammatory response from leukocytes by interfering with NFκB signaling, and prompts the launch of a clinical trial to address in vivo the clinical benefits of this promising agent.