S
Simon Jones
Researcher at University of Manchester
Publications - 1100
Citations - 45394
Simon Jones is an academic researcher from University of Manchester. The author has contributed to research in topics: Haskell & Functional programming. The author has an hindex of 92, co-authored 1012 publications receiving 39886 citations. Previous affiliations of Simon Jones include University of California, Berkeley & Microsoft.
Papers
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Posted ContentDOI
Network-based assessment of HDAC6 activity is highly predictive of pre-clinical and clinical responses to the HDAC6 inhibitor ricolinostat
Tizita Z. Zeleke,Qingfei Pan,Cody Chiuzan,Maika Onishi,Mariano J. Alvarez,Erin Honan,Min Yang,Pei Ling Chia,Partha Mukhopadhyay,Sean A. Kelly,Ruby Wu,Kathleen Fenn,Meghna S. Trivedi,Melissa K. Accordino,Katherine D. Crew,Dawn L. Hershman,Matthew Maurer,Simon Jones,Andrea Califano,Kevin Kalinsky,Jiyang Yu,Jose M. Silva +21 more
TL;DR: The results of the first clinical trial evaluating the activity of ricolinostat plus nab-paclitaxel in metastatic BC patients showed that the two agents can be safely combined, that clinical activity is identified specifically in patients with HR+/HER2- disease, and that the HDAC6 score was predictive of response.
Patent
Systems and methods for selectively decoupling a parallel extended instruction pipeline
TL;DR: In this paper, a light weight mechanism in the form of a condition code as seen by the main processor is designed to allow intelligent decision maximizing overall performance to be made in run-time if further instructions should be issued to the parallel extended pipeline based on the queue status.
Journal ArticleDOI
Breast cancer metastasis burden in sentinel nodes analysed using one-step nucleic acid amplification predicts axillary nodal status.
Thomas D. Milner,Thomas D. Milner,Simon de Lusignan,Simon Jones,P. Jackson,G.T. Layer,G.T. Layer,Mark Kissin,Tracey Irvine +8 more
TL;DR: Extent of sentinel lymph node positivity measured using OSNA predicts NSLN metastasis risk, aiding decisions surrounding axillary treatment.
Journal ArticleDOI
Incidence of household transmission of acute gastroenteritis (AGE) in a primary care sentinel network (1992-2017): cross-sectional and retrospective cohort study protocol.
Simon de Lusignan,Simon de Lusignan,Emmanouela Konstantara,Mark Joy,Julian Sherlock,Uy Hoang,Rachel Coyle,Filipa Ferreira,Simon Jones,Sarah J. O'Brien +9 more
TL;DR: This study used the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) primary care sentinel network, comprising data from 1 750 167 registered patients, and conducted a novel analysis using a ’household key', to identify patients within the same household.
Journal ArticleDOI
Case report of the first patient treated with ex-vivo autologous haematopoietic stem cell gene therapy transplant in mucopolysaccharidosis type IIIA
Jane Louise Kinsella,Heather J. Church,Wendy Ogden,Ceri Jones,Karen F. Buckland,Christine Rivat,Adrian J. Thrasher,Katie Snell,Diego Leon-Rico,Fred M. Vaz,Frits A. Wijburg,Simon Jones,Brian W. Bigger,Robert Wynn +13 more