M
Mariano J. Alvarez
Researcher at Columbia University
Publications - 69
Citations - 5730
Mariano J. Alvarez is an academic researcher from Columbia University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 26, co-authored 58 publications receiving 4687 citations. Previous affiliations of Mariano J. Alvarez include Fundación Instituto Leloir & National Scientific and Technical Research Council.
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Journal ArticleDOI
The transcriptional network for mesenchymal transformation of brain tumours
Maria Stella Carro,Wei Keat Lim,Mariano J. Alvarez,Robert J. Bollo,Xudong Zhao,Evan Y. Snyder,Erik P. Sulman,Sandrine L. Anne,Sandrine L. Anne,Fiona Doetsch,Howard Colman,Anna Lasorella,Kenneth Aldape,Andrea Califano,Antonio Iavarone +14 more
TL;DR: It is shown that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignantglioma.
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Functional characterization of somatic mutations in cancer using network-based inference of protein activity
Mariano J. Alvarez,Yao Shen,Federico M. Giorgi,Alexander Lachmann,B. Belinda Ding,B. Hilda Ye,Andrea Califano +6 more
TL;DR: A fraction of tumors is identified with aberrant activity of druggable oncoproteins despite a lack of mutations, and vice versa, and in vitro assays confirmed that VIPER-inferred protein activity outperformed mutational analysis in predicting sensitivity to targeted inhibitors.
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Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege.
Natalia Rubinstein,Mariano J. Alvarez,Norberto Walter Zwirner,Marta A. Toscano,Juan M. Ilarregui,Alicia I. Bravo,Jose Mordoh,Leonardo Fainboim,Osvaldo L. Podhajcer,Gabriel A. Rabinovich +9 more
TL;DR: In this article, the authors demonstrate that Galectin-1 signaling in activated T cells constitutes an important mechanism of tumor-immune escape and that blockade of this inhibitory signal can allow for and potentiate effective immune responses against tumor cells, with profound implications for cancer immunotherapy.
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A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
Celine Lefebvre,Presha Rajbhandari,Mariano J. Alvarez,Pradeep Bandaru,Wei Keat Lim,Mai Sato,Kai Wang,Pavel Sumazin,Manjunath Kustagi,Brygida Bisikirska,Katia Basso,Pedro Beltrao,Nevan J. Krogan,Jean-Charles Gautier,Riccardo Dalla-Favera,Andrea Califano +15 more
TL;DR: Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome, reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center.
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Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy.
Alvaro Aytes,Antonina Mitrofanova,Celine Lefebvre,Mariano J. Alvarez,Mireia Castillo-Martin,Tian Zheng,Tian Zheng,James A. Eastham,Anuradha Gopalan,Kenneth J. Pienta,Kenneth J. Pienta,Michael M. Shen,Andrea Califano,Cory Abate-Shen +13 more
TL;DR: Experimental validation shows that FOXM1 and CENPF function synergistically to promote tumor growth by coordinated regulation of target gene expression and activation of key signaling pathways associated with prostate cancer malignancy.