S
Simon Koplev
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 28
Citations - 7820
Simon Koplev is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Inflammation. The author has an hindex of 15, co-authored 24 publications receiving 4769 citations. Previous affiliations of Simon Koplev include University of Virginia & University of Copenhagen.
Papers
More filters
Posted ContentDOI
Transcriptome wide association study of coronary artery disease identifies novel susceptibility genes
Heribert Schunkert,Ling Li,Zhifen Chen,Moritz von Scheidt,Andrea Steiner,Ulrich Güldener,Simon Koplev,Angela Ma,Ke Hao,Calvin Pan,Aldons J. Lusis,Shichao Pang,Thorsten Kessler,Thorsten Kessler,Raili Ermel,Katyayani Sukhavasi,Arno Ruusalepp,Julien Gagneur,Jeanette Erdmann,Jason C. Kovacic,Jason C. Kovacic,Johan L.M. Björkegren,Johan L.M. Björkegren +22 more
TL;DR: Transcriptome-wide association studies (TWAS) explore genetic variants affecting gene expression for association with a trait as mentioned in this paper, which can be used to identify novel genes which are associated with CAD.
Journal ArticleDOI
Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy.
Itziar Frades,Ben Readhead,Letizia Amadori,Simon Koplev,Husain A. Talukdar,Heidi M. Crane,Paul K. Crane,Jason C. Kovacic,Joel T. Dudley,Chiara Giannarelli,Johan L.M. Björkegren,Johan L.M. Björkegren,Inga Peter +12 more
TL;DR: 3 commonly used ARTs were found altering the activity of AR-RGN, a regulatory gene network promoting foam cell formation and risk of CAD, by applying a novel systems pharmacology data analysis framework.
Posted ContentDOI
Probability-based detection of phosphoproteomic uncertainty reveals rare signaling events driven by oncogenic kinase gene fusion
Xavier Robin,Franziska Voellmy,Jesper Ferkinghoff-Borg,Conor Howard,Tom Altenburg,Mathias Engel,Craig D. Simpson,Gaye Saginc,Simon Koplev,Edda Klipp,James Longden,James Longden,Rune Linding +12 more
TL;DR: A novel Bayesian method for estimating protein concentration and phosphorylation site occupancy ratios from mass spectrometry experiments is described, using a dataset investigating the impact of the PRKAR1A-RET gene fusion in immortalized thyroid cells.
Journal ArticleDOI
Publisher Correction: Transcriptome-wide association study of coronary artery disease identifies novel susceptibility genes
Lin Li,Zhifen Chen,Moritz von Scheidt,Shuang yue Li,Andrea Steiner,Ulrich Güldener,Simon Koplev,Angela Ma,Ke Hao,Calvin Pan,Aldons J. Lusis,Shichao Pang,Thorsten Kessler,Raili Ermel,Katyayani Sukhavasi,Arno Ruusalepp,Julien Gagneur,Jeanette Erdmann,Jason C. Kovacic,Johan Björkegren,Heribert Schunkert +20 more
Posted ContentDOI
Loss of soluble guanylyl cyclase in platelets contributes to atherosclerotic plaque formation and vascular inflammation
Carina Mauersberger,Hendrik B. Sager,Jana Wobst,Tan An Dang,L. Lambrecht,Simon Koplev,Simon Koplev,M. Stroth,N. Bettaga,Jens Schlossmann,Frank Wunder,Andreas Friebe,J.L.M. Bjoerkegren,J.L.M. Bjoerkegren,J.L.M. Bjoerkegren,Lisa Dietz,Peter Sandner,Oliver Soehnlein,Heribert Schunkert,Thorsten Kessler +19 more
TL;DR: In this paper, the contribution of platelet sGC to atherosclerosis and the therapeutic potential of targeting sGC in coronary artery disease (CAD) risk was investigated and the role of platelets in atherosclerotic plaque formation remains incompletely understood.