S
Simon P. Lee
Researcher at University of Dundee
Publications - 15
Citations - 4335
Simon P. Lee is an academic researcher from University of Dundee. The author has contributed to research in topics: Filaggrin & Atopic dermatitis. The author has an hindex of 11, co-authored 15 publications receiving 4052 citations.
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Journal ArticleDOI
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Colin N. A. Palmer,Alan D. Irvine,Ana Terron-Kwiatkowski,Yiwei Zhao,Haihui Liao,Simon P. Lee,David Goudie,Aileen Sandilands,Linda E. Campbell,Frances J.D. Smith,Grainne M. O'Regan,Rosemarie Watson,Jo E Cecil,Sherri J. Bale,John G. Compton,John J. DiGiovanna,John J. DiGiovanna,Philip Fleckman,Sue Lewis-Jones,Gehan Arseculeratne,Ann Sergeant,Colin S. Munro,Brahim El Houate,Ken McElreavey,Liselotte Brydensholt Halkjaer,Hans Bisgaard,Somnath Mukhopadhyay,Somnath Mukhopadhyay,W.H. Irwin McLean +28 more
TL;DR: It is shown that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis.
Journal ArticleDOI
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
Stephan Weidinger,Thomas Illig,Hansjörg Baurecht,Alan D. Irvine,Elke Rodriguez,Amalia Diaz-Lacava,Norman Klopp,Stefan Wagenpfeil,Yiwei Zhao,Haihui Liao,Simon P. Lee,Colin N. A. Palmer,Claudia Jenneck,Laura Maintz,Tobias Hagemann,Heidrun Behrendt,Johannes Ring,Markus M. Nöthen,W.H. Irwin McLean,Natalija Novak +19 more
TL;DR: In this article, a family-based approach revealed prominent associations between the 2 loss-of-function FLG mutations and AD, as previously observed in a traditional Mendelian linkage analysis and case-control cohort analysis approach.
Journal ArticleDOI
The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study
John Henderson,Kate Northstone,Simon P. Lee,Haihui Liao,Yiwei Zhao,Marcus Pembrey,Somnath Mukhopadhyay,George Davey Smith,Colin N. A. Palmer,W.H. Irwin McLean,Alan D. Irvine +10 more
TL;DR: FLG mutations are strong genetic determinants of eczema, early wheeze, asthma in the context of ecZema, and atopic sensitization, with increased duration of disease and greater risk of asthma and multiple allergic sensitizations.
Journal ArticleDOI
Null Mutations in the Filaggrin Gene (FLG) Determine Major Susceptibility to Early-Onset Atopic Dermatitis that Persists into Adulthood
Jonathan Barker,Colin N. A. Palmer,Yiwei Zhao,Haihui Liao,Peter R. Hull,Simon P. Lee,Michael H. Allen,SJ Meggitt,Nick J. Reynolds,Richard C. Trembath,W.H. Irwin McLean +10 more
TL;DR: The data conclusively demonstrate that identification of FLG null alleles is an indicator of a poor prognosis in AD, predisposing to a form of eczema that starts in early infancy and persists into adulthood.
Journal ArticleDOI
Filaggrin null mutations are associated with increased asthma severity in children and young adults.
Colin N. A. Palmer,Tahmina Ismail,Simon P. Lee,Ana Terron-Kwiatkowski,Yiwei Zhao,Haihui Liao,Frances J.D. Smith,W.H. Irwin McLean,Somnath Mukhopadhyay +8 more
TL;DR: FLG mutations are associated not only with Eczema-associated asthma susceptibility but also with asthma severity independent of eczema status, and these mutations were significantly associated with greater disease severity for asthma.